Reflecting work in the Raj Lab
The selective incorporation of post-translational modifications, PTMs, into proteins remains a key challenge in chemical biology, particularly for modifications like arginine carbonylation, which plays a crucial role...
Reflecting work in the Merck Labs
The total synthesis and process development of enlicitide decanoate, MK-0616, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9, PCSK9, represents a major breakthrough in macrocyclic peptide...
Reflecting work in the Raj Lab
Understanding how proteins interact with biological metabolites is crucial for deciphering biological processes and advancing therapeutic strategies. This study focuses on a specific class of metabolites—α,β-unsaturated carbonyls, particularly acrolein-derived...
Reflecting work in the Deming Lab
Self-assembled polymeric vesicles that respond to biologically relevant stimuli have significant potential in drug delivery and synthetic biology. While many stimuli-responsive assemblies disassemble upon activation, invertible vesicles...
Reflecting work in the Suga & Vinogradov Labs
α,β-Dehydroalanine, ΔAla, is a highly reactive nonproteinogenic amino acid that serves as a versatile handle for modifying peptides, natural products, NPs, and proteins. While many ΔAla functionalization...
Reflecting work in the Phan Group
Ribosomally synthesized and post-translationally modified peptides, RiPPs, represent an expanding class of natural products distinguished by their extensive post-translational modifications. Among the enzymatic systems...
Reflecting work in the Hartrampf Lab
Solid-phase peptide synthesis, SPPS, and native chemical ligation, NCL, are powerful methods for obtaining peptides and proteins that are otherwise inaccessible...
Reflecting work in the Nowick Lab
Vancomycin, a cornerstone antibiotic for Gram-positive infections, faces diminishing efficacy due to the emergence of vancomycin-resistant Enterococci, VRE, and vancomycin-resistant...
Reflecting work in the Agarwal Lab
Brominated intermediates have long been favored in organic synthesis for their chemical versatility, particularly in transition-metal-assisted bond-forming reactions. The Agarwal and van der Donk study represents a significant leap...
Reflecting work in the NSF CGEM
The ability to precisely manipulate the peptide backbone remains one of the fundamental challenges in biomolecular engineering. While ribosomal translation and peptide synthesis methods allow for modifications...
Reflecting work in the Guha Lab
Researchers in the Samit Guha Group at Jadavpur University, Kolkata, India, published in Bioconjugate Chemistry, report a groundbreaking approach to cancer imaging...
Reflecting work in the Liu Group
To address the limitations of current methods for peptide macrocyclization, which often rely on nonspecific small-molecule linkers...
Reflecting work in the Woolfson and Oliver Labs
To address the formidable challenge of binding and orienting multiple small molecules for directed chemical reactions, researchers in the Woolfson and Oliver groups at the University of Bristol, published in...
Reflecting work in the Knudsen Group
Researchers in the Knudsen Group at the University of Aarhus, Denmark, published in Biochemistry, report the construction of a Saccharomyces cerevisiae-specific SICLOPPS library of 80 million members...
Reflecting work in the Proulx Lab
Published in the Journal of the American Chemical Society, researchers in the Proulx group at the North Carolina State University at Raleigh, present the first approach to controlled metal chelation of peptide backbones...
Reflecting work in the Ding Lab
Published in ACS Chemical Biology, researchers in the Ding Group at the University of Florida, reconstructed prunipeptin biosynthesis from Streptomyces coelicolor...
Reflecting work in the Payne Lab
Chemokines are small proteins involved in recruiting leukocytes to sites of inflammation via interactions with specific cell surface receptors. CCL22 is a chemokine known to play a critical role in...
Reflecting work in the Schultz Lab
Nicotinamide-containing cofactors play an essential role in many enzymes that catalyze two-electron redox reactions. However, it is difficult to engineer nicotinamide binding sites into proteins due to the extended nature...
Automated Peptide Synthesis
In this sponsored content by Gyros Protein Technologies, discover how automated systems revolutionize peptide production with enhanced efficiency and reproducibility.
The evolution from manual to automated solid-phase peptide synthesis, SPPS, has transformed research workflows, significantly reducing human error while enabling walk-away operations and parallel processing capabilities.
Advanced features like microfluidic design, induction heating, and real-time UV monitoring create optimal conditions even for challenging sequences, substantially improving yield and purity. This article shows you how to harness these innovations for your peptide research needs.
Women in Peptide Science
On February 11th, the world celebrates the International Day of Women and Girls in Science, a day dedicated to promoting full and equal access to and participation in science for women and girls.
In the field of peptide science, women have made significant contributions, advancing our understanding of peptides and their applications. The American Peptide Society, APS, has recognized several outstanding female scientists over the past five years for their exceptional work.
What Current Members Say
“APS provides a forum for connecting graduate students, postdocs and working professionals with each other based on shared professional skills and interests. When it comes time to look for their next position, APS members can count on a strong network of like-minded scientists who value their skills and accomplishments.”
Joshua Kritzer
Professor
Tufts University
"The APS has been an integral part of my PhD experience. Between introducing me to a broad array of peptide science, allowing me to meet and develop relationships with colleagues near and far, and providing me with the opportunity to present, discuss, and get feedback on my own research, APS has provided a foundation for the beginning of my career."
Zoë Adams
Ph.D. - Postdoctoral Research Fellow
Scripps Research
“I have been a member of APS since I was a graduate student because of the benefits and opportunities it provided scientists at that stage of my career. Through the years, I have continued to be a member so I can engage with the top researchers working in peptide science from around the globe.”
Marcos Pires
Associate Professor of Chemistry
University of Virginia
Peptide Synthesis for Beginners
Explore this in-depth tutorial on peptide synthesis, featuring contributions from the APS Website Committee and other researchers in the field.
Free Membership
Membership is free and open to graduate and undergraduate students, postdocs, professionals, and retired professionals, with an interest in peptides or a related scientific field.
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