Reflecting work in the D'Amelio Lab
As antibiotic resistance surges worldwide, the search for effective new therapeutics has led scientists to a surprising source: the venom of Bungarus fasciatus, the banded krait. From this venom, researchers have isolated Cathelicidin-BF...
Reflecting work in the Tezcan Group
Isopeptide bonds, IPBs, — covalent linkages between the side chains of lysine and asparagine/glutamine or aspartate/glutamate — are remarkable for their chemical resilience and structural significance...
Reflecting work in the Raj Lab
The selective incorporation of post-translational modifications, PTMs, into proteins remains a key challenge in chemical biology, particularly for modifications like arginine carbonylation, which plays a crucial role...
Reflecting work in the Merck Labs
The total synthesis and process development of enlicitide decanoate, MK-0616, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9, PCSK9, represents a major breakthrough in macrocyclic peptide...
Reflecting work in the Raj Lab
Understanding how proteins interact with biological metabolites is crucial for deciphering biological processes and advancing therapeutic strategies. This study focuses on a specific class of metabolites—α,β-unsaturated carbonyls, particularly acrolein-derived...
Reflecting work in the Deming Lab
Self-assembled polymeric vesicles that respond to biologically relevant stimuli have significant potential in drug delivery and synthetic biology. While many stimuli-responsive assemblies disassemble upon activation, invertible vesicles...
Reflecting work in the Suga & Vinogradov Labs
α,β-Dehydroalanine, ΔAla, is a highly reactive nonproteinogenic amino acid that serves as a versatile handle for modifying peptides, natural products, NPs, and proteins. While many ΔAla functionalization...
Reflecting work in the Phan Group
Ribosomally synthesized and post-translationally modified peptides, RiPPs, represent an expanding class of natural products distinguished by their extensive post-translational modifications. Among the enzymatic systems...
Reflecting work in the Hartrampf Lab
Solid-phase peptide synthesis, SPPS, and native chemical ligation, NCL, are powerful methods for obtaining peptides and proteins that are otherwise inaccessible...
Reflecting work in the Nowick Lab
Vancomycin, a cornerstone antibiotic for Gram-positive infections, faces diminishing efficacy due to the emergence of vancomycin-resistant Enterococci, VRE, and vancomycin-resistant...
Reflecting work in the Agarwal Lab
Brominated intermediates have long been favored in organic synthesis for their chemical versatility, particularly in transition-metal-assisted bond-forming reactions. The Agarwal and van der Donk study represents a significant leap...
Reflecting work in the NSF CGEM
The ability to precisely manipulate the peptide backbone remains one of the fundamental challenges in biomolecular engineering. While ribosomal translation and peptide synthesis methods allow for modifications...
Reflecting work in the Guha Lab
Researchers in the Samit Guha Group at Jadavpur University, Kolkata, India, published in Bioconjugate Chemistry, report a groundbreaking approach to cancer imaging...
Reflecting work in the Liu Group
To address the limitations of current methods for peptide macrocyclization, which often rely on nonspecific small-molecule linkers...
Reflecting work in the Woolfson and Oliver Labs
To address the formidable challenge of binding and orienting multiple small molecules for directed chemical reactions, researchers in the Woolfson and Oliver groups at the University of Bristol, published in...
Reflecting work in the Knudsen Group
Researchers in the Knudsen Group at the University of Aarhus, Denmark, published in Biochemistry, report the construction of a Saccharomyces cerevisiae-specific SICLOPPS library of 80 million members...
Reflecting work in the Proulx Lab
Published in the Journal of the American Chemical Society, researchers in the Proulx group at the North Carolina State University at Raleigh, present the first approach to controlled metal chelation of peptide backbones...
Reflecting work in the Ding Lab
Published in ACS Chemical Biology, researchers in the Ding Group at the University of Florida, reconstructed prunipeptin biosynthesis from Streptomyces coelicolor...
Automated Peptide Synthesis
In this sponsored content by Gyros Protein Technologies, discover how automated systems revolutionize peptide production with enhanced efficiency and reproducibility.
The evolution from manual to automated solid-phase peptide synthesis, SPPS, has transformed research workflows, significantly reducing human error while enabling walk-away operations and parallel processing capabilities.
Advanced features like microfluidic design, induction heating, and real-time UV monitoring create optimal conditions even for challenging sequences, substantially improving yield and purity. This article shows you how to harness these innovations for your peptide research needs.
The Wenshe Liu Lab
The Wenshe Liu Lab at Texas A&M University applies cutting-edge chemical biology techniques to advance drug discovery. Our work spans a broad spectrum, from cell biology and target identification to traditional medicinal chemistry. The lab operates across two Texas A&M campuses: one within the Department of Chemistry in College Station and the other at the Institute of Biosciences and Technology in Houston.
We foster a collaborative research environment that brings together scientists from diverse backgrounds. The lab currently includes 10 postdoctoral research associates and 18 graduate students representing 10 countries, all mentored by Professor Wenshe Liu. In addition to leading the lab, Wenshe serves as Director of the Texas A&M Drug Discovery Center, with Professor J. Trae Hampton as Manager.
Stay tuned for more lab features, and don’t miss the chance to get your lab featured!
Please contact Lars Sahl to get involved!
T-Shirts for a Cause!
Celebrate the spirit of discovery with our exclusive Peptides Rising T-shirt, available by pre-order until May 1st. Proceeds support the APS Student Travel Grant Fund, helping the next generation of researchers share their work. Shirts will be available for pick-up at registration — a thoughtful choice for both style and purpose. Place your order today!
What Current Members Say
"My membership in the American Peptide Society and participation in the biennial APS Symposia has fostered scientific collaborations with trailblazing scientists from academia and industry, who are pushing the boundaries of peptide and protein chemistry into new scientific arenas. The strongly diverse, inclusive and welcoming aspects of the APS have and will continue to provide a great opportunity for the education and professional development of young peptide scientists from all over the world."
Champak Chatterjee
Professor, Department of Chemistry
University of Washington
"The American Peptide Society is at the forefront of showcasing innovative research and emerging trends in the field. The symposiums are a combination of inspiration and knowledge, essential for all peptide enthusiasts in academia and pharma to stay ahead in peptide science."
Danny Chou
Assistant Professor of Pediatrics Endocrinology
Stanford University, School of Medicine
The American Peptide Society has for many years been central to advancing and promoting peptide research through activities such as regular symposiums, the Peptide Science Journal, and ongoing webinars and news highlights. These efforts are an essential contribution to the field which benefits both the academic and industrial communities.
Jon Collins
Director of Business Development
CEM
Peptide Synthesis for Beginners
Explore this in-depth tutorial on peptide synthesis, featuring contributions from the APS Website Committee and other researchers in the field.
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Membership is free and open to graduate and undergraduate students, postdocs, professionals, and retired professionals, with an interest in peptides or a related scientific field.
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