Reflecting work in the Yudin Lab
Helical secondary structures, namely α- and 310-helices, comprise >60% of all secondary structures observed at protein–protein interactions, PPIs, and are responsible for the mediation of many biological...
Reflecting work in the Wennemers Lab
In a study from the Wennemers Lab at ETH, Zūrich, published in JACS, group members present an organocatalytic kinetic resolution to yield enantiomerically enriched β-branched aldehydes and γ-nitroaldehydes with three...
Reflecting work in the The Suga Lab
Nonproteinogenic amino acids, including D-α-, β-, and γ-amino acids, present in bioactive peptides play pivotal roles in their biochemical activities and proteolytic stabilities...
Reflecting work in the Malmsten Lab
Published in Advanced Functional Materials, work by members of the Martin Malmsten group at the University of Lund, Sweden, explores the coating of photocatalytic nanoparticles with antimicrobial peptides...
Reflecting work in the Martin and Panwar Labs
Membrane–peptide interactions are key to the formation of helical intermediates in the early stages of amyloidogenesis. Aqueous solutions of 2,2,2-trifluoroethanol...
Reflecting work in the Hamley Group
Chirality plays a crucial role in the self-assembly of biomolecules in nature. Peptides show chirality-dependent conformation and self-assembly. Lipidation of peptides occurs in vivo...
Reflecting work in the Steuer Group
Published in Peptide Science, the Steuer Group at ETH, Zūrich, presents "PICKAPEP," an application developed for Mac and Windows, enabling the virtual construction...
Reflecting work in the Voigt Lab
Natural melanin polymers, biosynthesized from free tyrosine, assemble into microstructures that interact with light, producing a wide range of photonic properties. These structures...
Reflecting work in the Evans Lab
Ion transport is essential to energy storage, cellular signalling and desalination. Polymers have been explored for decades as solid-state electrolytes by either adding salt to polar polymers...
Reflecting work in the Kellermeier Lab
In a recent study, published in Advanced Functional Materials, researchers in the Kellermeier Lab at BASF, have used phage display screening to identify peptide motifs...
Reflecting work in the Bhattacharya Lab
Circularly polarized luminescence, CPL, is gaining interest across various disciplines, including materials science, pharmaceuticals, and sensing technologies. Organic molecules...
Reflecting work in the Pal and Balakrishnan Labs
Crystalline materials exhibiting non-centrosymmetry and possessing substantial surface dipole moments play a critical role in piezoelectricity. Designing biocompatible self-assembled materials...
Reflecting work in the The Huang Lab
Global pandemics caused by pathogenic viruses have highlighted the need to develop effective and sustainable materials to defend against these viruses. However, most commercial viral disinfection...
Reflecting work in the Gopi Lab
Crystalline materials exhibiting non-centrosymmetry and possessing substantial surface dipole moments play a critical role in piezoelectricity. Designing biocompatible self-assembled materials...
Reflecting work in the Kodadek Lab
Many disease-causing proteins lack deep, readily ligandable pockets. Macrocyclic peptides and peptidomimetic compounds are one class of molecules that have shown promise in engaging these...
Reflecting work in the Grossmann Lab
The inhibition of intracellular protein-protein interactions is challenging, in particular, when involved interfaces lack pronounced cavities. The transcriptional co-activator protein...
Reflecting work in the Reflecting recent work in the Su, Partridge and Verma Labs
Macrocyclic peptides show promise in targeting high-value therapeutically relevant binding sites due to their high affinity and specificity. However, their clinical application...
Reflecting work in the Mapp Lab
A short, amphipathic peptide derived from transcriptional activators is transformed from a weak inhibitor of transcriptional protein–protein interactions (PPIs) to an effective inhibitor...
The Kiessling Lab – October Lab of the Month
Led by Professor Laura Kiessling at MIT, the Kiessling lab has a passion for carbohydrates — the biomolecules coating every cell on Earth. This coat, termed the glycocalyx, serves as a critical conduit of information.
Using chemical biology, the Kiessling lab interrogates ways in which the glycocalyx enables microbes to escape host immune recognition. The group harnesses synthetic chemistry, molecular dynamics simulations, molecular and cell biology, as well as immunology to unpack the importance of glycan-protein interactions at the forefront of many diseases.
Stay tuned for more exciting features, and don’t miss the chance to get your lab featured! Please contact Lars Sahl to get involved!
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University of Virginia
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