Recent Peptide Research and News
Reflecting work in the Wu, Tsai, and Yin Groups
Disulfide-rich peptides, DRPs, are renowned for their stability and therapeutic promise, yet their natural structures offer limited flexibility for evolution or functional adaptation. In an innovative and collaborative study, researchers...
Reflecting work in the Serianni Group
The conformational behavior of alanine dipeptide, Ac-L-Ala-NHMe, 1, has long made it a model compound in molecular simulation studies. However, despite numerous investigations using molecular dynamics, MD, and quantum mechanical, QM, calculations, a rigorous...
Reflecting work in the Craik, Gachon, and Chan Labs
Obesity is a leading contributor to global disease burden and a primary risk factor for type 2 diabetes, yet current treatments often lack specificity and long-term efficacy. In a groundbreaking collaborative study, published...
Reflecting work in the Wu, Chen, Zhang, and Luan Groups
While immune checkpoint blockade, ICB, therapies have transformed cancer immunotherapy, tumors such as melanoma frequently exploit the CD47-SIRPα axis to evade macrophage-mediated clearance. Antibody-based CD47 blockade, though...
Reflecting work in the Jiang and Wang Labs
Peptides capable of folding into defined secondary structures serve as promising modular building blocks for supramolecular materials. However, conventional approaches to peptide-based self-assembly are often constrained by environmental...
Reflecting work in the Futaki Group
The delivery of biomacromolecules directly into the cytosol remains a central challenge in therapeutic peptide science. Coacervate-based systems offer a promising platform, yet many are hampered by instability in physiological conditions and diminished performance...
Reflecting work in the Gellman Lab
The rational construction of stable hetero-oligomeric protein complexes with defined subunit composition is a central challenge in molecular design. In this study, published in the Journal of the American Chemical Society, researchers in the Gellman Lab...
Reflecting work in the van der Donk Group
Ribosomally synthesized and posttranslationally modified peptides, RiPPs, represent one of the most structurally diverse classes of natural products, yet many RiPP families remain biosynthetically uncharacterized...
Reflecting work in the The Tal-Gan Group
Streptococcus constellatus, a member of the Streptococcus anginosus group, SAG, is an opportunistic pathogen commonly found in the human oral and gastrointestinal microbiota. While often commensal, it has increasingly been implicated in severe purulent infections, particularly in immunocompromised individuals. Despite its emerging clinical relevance...
Reflecting work in the Proulx Group
This study demonstrates that a key determinant of this reactivity is the choice of solvent. By shifting from aqueous buffer to a mixed organic solvent system, MeOH/DCE, the authors observed a pronounced shift in the oxidation pathway, favoring productive...
Reflecting work in the The Süssmuth Group
In this study, researchers from the Süssmuth group at the Technische Universität Berlin, published in the Journal of the American Chemical Society, elucidated the structure of AFC-BC11 as an N-acyl tetrapeptide with a distinctive architecture. The molecule is...
Reflecting work in the Dahlén and Andaloussi Groups
In this collaborative study, published in Bioconjugate Chemistry by researchers from the Dahlén group at Astra-Zeneca, Gothenburg, Sweden, and the Andaloussi team at the Karolinska Institutet, Stockholm, Sweden, the authors present...
Reflecting work in the Wilson Lab
Protein–protein interactions, PPIs, are fundamental to cellular regulation, yet targeting them therapeutically remains challenging due to their extensive, shallow interfaces. Peptides offer an attractive solution, providing structural fidelity...
Reflecting work in the Kwon Lab
Traumatic brain injury, TBI, remains a profound and unresolved clinical challenge, responsible for long-term disability in both civilian and military populations. The lack of effective pharmacological interventions...
Reflecting work in the Tal-Gan Lab
Streptococcus cristatus, a commensal member of the oral microbiota and recently reclassified from Streptococcus oligofermentans, has emerged as a promising candidate in the pursuit of biotherapeutics targeting oral pathogens. A comprehensive...
Reflecting work in the Carik and Malins Labs
This comprehensive review from the labs of David Craik and Lara Malins at Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, at the University of Queensland, published in Biochemistry, highlights the powerful...
Reflecting work in the Schneider Lab
Published in the Journal of the American Chemical Society, researchers in the lab of Dr. Joel P. Schneider at NIH, have unveiled a groundbreaking molecular design strategy that shifts gel-forming peptides into the crystalline state...
Reflecting work in the Arora Group
In a major step forward, researchers in the Arora Group at the New York University, have now developed a rationally designed proteomimetic receptor capable of selectively trapping MYC in its biologically active conformation...
Automated Peptide Synthesis
In this sponsored content by Gyros Protein Technologies, discover how automated systems revolutionize peptide production with enhanced efficiency and reproducibility.
The evolution from manual to automated solid-phase peptide synthesis, SPPS, has transformed research workflows, significantly reducing human error while enabling walk-away operations and parallel processing capabilities.
Advanced features like microfluidic design, induction heating, and real-time UV monitoring create optimal conditions even for challenging sequences, substantially improving yield and purity. This article shows you how to harness these innovations for your peptide research needs.
The Nicola D'Amelio Lab
The D’Amelio Lab is part of the Enzyme and Cell Engineering Unit, UMR 7025 CNRS, with active sites at Université de Picardie Jules Verne, UPJV, in Amiens and Université de Technologie de Compiègne, UTC, in Compiègne, France. Co-directed by Professors Karsten Haupt, Bérangère Avalle, and Catherine Sarazin, the lab is led by Professor Nicola D’Amelio and is internationally recognized for its work in structural biology, biomedicine, and peptide engineering.
Professor D’Amelio’s team is at the forefront of peptide-based research targeting antimicrobial resistance, cancer, and neurodegenerative disease. Their ADAPTABLE platform—an interactive database of antimicrobial peptides—guides the rational design of therapeutic peptides, while ongoing projects explore peptide interference in cancer signaling, microbiome-based delivery systems, and blood-brain barrier-penetrating therapeutics for Alzheimer’s.
Stay tuned for more lab features, and don’t miss the chance to get your lab featured!
Please contact Lars Sahl to get involved!
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Tufts University
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University of Alberta
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Marcos Pires
Associate Professor of Chemistry
University of Virginia
Peptide Synthesis for Beginners
Explore this in-depth tutorial on peptide synthesis, featuring contributions from the APS Website Committee and other researchers in the field.
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