Peptide Publications Archive
Engineering Disorder
Horne Group
Researchers in the Horne Group at the University of Pittsburgh, published in Biochemistry, set out to develop a systematic method for manipulating the unfolded …
Switching Max On
Jbara Lab
A photocaged Max transcription factor sits dark and silent until a flash of UV light removes two chemical masks and restores full DNA-binding activity within …
Inside-Out Peptides
Gladysz Group
Macrobicyclic peptides can flip inside-out via homeomorphic isomerization, creating distinct structures with different biological properties.
Greener Peptide Couplings
Albericio & de la Torre Group
Researchers in the Albericio & de la Torre Group at the University of KwaZulu-Natal, published in Organic Letters, introduced Cyclover as a commercially accessible …
Blocking Nuclear Entry
Mizuno Group
Peptide-based therapeutics hold enormous promise for modulating intracellular signaling, but their impact has been limited by poor membrane permeability. Most peptide drugs remain confined to …
Split Lasso Discovery
Seyedsayamdost & Moon Groups
Marine actinomycete produces anticancer lasso peptides from a split biosynthetic gene cluster separated by over 2 million base pairs.
Myeloma in Focus
Shokeen Group
Researchers in the Shokeen Group at Washington University in St. Louis, published in Bioconjugate Chemistry, identified a novel CD38-binding peptide sequence, HAPWFRGGGGS, through phage …
Backbone Sensitivity
Cryle Lab
Researchers supervised by Professors Julien Tailhades and Max J. Cryle from Monash University, Australia, published in ACS Chemical Biology, have developed a chemoenzymatic strategy …
NMR Double Agent
Liu Lab
Researchers in the Liu Group at the Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, published in J. Am. Chem. Soc. …
Peptides Deliver Fluoride
Gouverneur Lab
Fluorine is among the most consequential substituents in medicinal chemistry, improving metabolic stability, membrane permeability, and target binding across a broad range of drug candidates
Unwinding RNA Delivery
Dulin Lab
Researchers in the Dulin Group at Vrije Universiteit Amsterdam investigated the biophysical effects of two peptides derived from the tomato aspermy virus 2b, TAV2b, protein …
Convergent Bradykinin Mimicry
Robinson Lab
Researchers in the Robinson Group at the University of Queensland, published in Science, demonstrated that bradykinin-like peptides found in hymenopteran venoms and anuran skin …
Site-Free Ligation
Hua Fu Lab
Researchers in the Fu Group at Tsinghua University in Beijing, published in Org. Lett., have developed a new chemoselective peptide ligation strategy, hydroxylamine-involved ligation, …
Jujube Unlocked
Kersten Lab
Researchers in the Kersten Group at the University of Michigan, published in J. Am. Chem. Soc., identified candidate biosynthetic genes in the genome of …
Intracellular Peptide Stapling
Mason Lab
Researchers in the Mason Group at the University of Bath, published in Cell Chemical Biology, developed a platform called intracellular-cyclization TBS that merges chemical …
Safety Catch Strategy
Albericio Lab
Researchers supervised by Professor Fernando Albericio at the University of KwaZulu-Natal developed a new family of safety-catch protecting groups based on the phenylthioethyl, Pte, and …
Ginkgo Degrader
Tam Lab
Researchers in the Tam Group at Nanyang Technological University identified a hyperdisulfide-constrained peptide from Ginkgo biloba nuts, termed β-ginkgotide β-gB1, as a first-in-class
Frankenproteins Block Myc
Shin Lab
The proto-oncogene MYC is dysregulated in more than 70% of human cancers and drives some of the most aggressive subtypes of breast cancer. Triple-negative breast …
Lasso Peptide Progress
Craik Lab
In a new Perspective published in the Journal of the American Chemical Society, Professor David J. Craik and colleagues at the University of Queensland's …
Barrier Shuttle Peptides
Norton Lab
Researchers supervised by Professor Raymond S. Norton at Monash University, Australia, published in the International Journal of Peptide Research and Therapeutics, developed a modular …
Targeted Fusion Inhibitors
Cheloha Lab
Researchers in the Cheloha Group at the National Institutes of Health, published in the Journal of the American Chemical Society, have developed nanobody-fusion inhibitor …
Programmable Hydrogel Mechanics
Pashuck Lab
Researchers in the Pashuck Group at Lehigh University, published in the Journal of the American Chemical Society, developed a modular approach that harnesses self-assembling …
Hemostatic Protein Polymers
Nash Group
Researchers supervised by Professor Michael A. Nash at the University of Basel, published in the Journal of the American Chemical Society, engineered a library …
Remote Stereocontrol
Miller Lab
Researchers in the Miller Group at Yale University, published in the Journal of the American Chemical Society, have developed guanidinylated peptide ligands that enable …