Ra Pharmaceuticals, Inc., has announced that it has received a development milestone payment under its collaboration agreement with Merck, known as MSD outside the US and Canada. The milestone payment is associated with the companies' collaboration...

Natural product discovery has been at the root of modern drug design, and it continues to play a vital role as there is renewed focus on orally available peptide therapeutics. In particular, macrocyclic peptides...

Amphipathic peptides with alternating polar and nonpolar amino acid sequences efficiently selfassemble into functional β-sheet fibrils as long as the nonpolar residues have sufficient hydrophobicity...

High-resolution structure-activity analysis of polypeptides requires amino acid structures that are not present in the universal genetic code. Examination of peptide and protein...

Although EGFR is a highly sought-after drug target, inhibitor resistance remains a challenge. As an alternative strategy for kinase inhibition, researchers in the...

The identification and quantification of proteins lags behind DNA-sequencing methods in scale, sensitivity, and dynamic range. In work published in Nature Biotechnology, researchers in the Marcotte Lab we show that sparse...