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Backbone N-Methylation

Wilson Lab

Reflecting recent work in the Wilson lab

A significant challenge in chemical biology is to understand and modulate protein–protein interactions, PPIs. Given that many PPIs involve a...

 

Macrocyclic Peptides

Kodadek Lab

Reflecting recent work in the Kodadek lab

Macrocyclic peptides, MPs, are a class of compounds that have been shown to be particularly well suited for engaging difficult protein targets. However, their utility...

 

Peptide Receptors

Checco Lab

Reflecting recent work in the Checco lab

Peptide–receptor interactions play critical roles in a wide variety of physiological processes. Methods to link bioactive peptides covalently to unmodified receptors...

 

Backbone Modification

Horne Lab

Reflecting recent work in the Horne lab

Targeted protein backbone modification can recreate tertiary structures reminiscent of folds found in nature on artificial scaffolds with improved biostability...

 

Site-Specific Probes

Jackson Lab

Reflecting recent work in the Jackson lab

Proteins produced with leucine analogues, where CH2F groups substitute specific methyl groups, can readily be probed by 19F NMR spectroscopy...

 

Triceptide Biocatalysts

Morinaka Lab

Reflecting recent work in the Morinaka lab

Triceptides are a class of ribosomally synthesized and post-translationally modified peptides defined by an aromatic C(sp2) to Cβ(sp3) bond...

 

Ephrin Receptors

Sawyer Lab

Reflecting recent work in the Sawyer lab

Ephrin, Eph, receptors are the largest family of receptor tyrosine kinases. Interactions between Eph receptors and their membrane-bound ephrin protein ligands are...

 

Lasso Peptides

Hartrampf Lab

Reflecting recent work in the Hartrampf lab

As the chemical space of MccJ25 analogues accessible through purely biological methods is also limited, researchers in the Hartrampf Lab propose a hybrid approach...

 

Antifungal Resistance

Rubini Lab

Reflecting recent work in the Rubini lab

The pursuit of novel antifungal agents is imperative to tackle the threat of antifungal resistance, which poses major risks to both human health and to food security...

 

Custom Click Biochemistry

Yang Lab

Reflecting recent work in the Yang lab

The development of oligomeric glucagon-like peptide-1, GLP-1, and GLP-1-containing coagonists holds promise for enhancing the therapeutic potential of the GLP-1-based drugs...

 

CGRP-Responsive Receptor

Sexton Lab

Reflecting recent work in the Sexton lab

Inhibition of calcitonin gene-related peptide, CGRP, or its cognate CGRP receptor, CGRPR, has arisen as a major breakthrough in the treatment...

 

Proline Conformation

Zondlo Lab

Reflecting recent work in the Zondlo lab

Using Dfp, researchers in the Zondlo lab at the University of Delaware, published in Biochemistry, discovered that the stable polyproline II helix, PPII...

 

Graspetide Biosynthesis

Link Lab

Reflecting recent work in the Link lab

The ribosomally synthesized and post-translationally modified peptide, RiPP, superfamily of natural products includes many examples of cyclic peptides with diverse...

 

Peptide Imidazolones

VanVeller Lab

Reflecting recent work in the VanVeller lab

Published in JACS, researchers in the VanVeller Group at Iowa State University, present a tandem amidine installation and cyclization with an...

 

Peptide Gels

Schneider Lab

Reflecting recent work in the Schneider lab

Researchers in the Schneider lab, published in Angewandte Chemie, Intl. Ed., discuss how peptide nucleic acids, PNAs, are employed in the design...

 

Peptide & Enzyme Catalysts

Wennemers Lab

Reflecting recent work in the Wennemers lab

Enzymes and peptide catalysts consist of the same building blocks but require vastly different environments to operate best. Published in Angewandte...

 

Self-Assembled Nanofibers

Sabatino Lab

Reflecting recent work in the Sabatino lab

Amphiphilic peptide sequences are conducive to secondary structures that self-assemble into higher-ordered peptide nanostructures. A select set...

 

Novel Substrate Prediction

Parker Lab

Reflecting recent work in the Parker lab

The TAM family of receptor tyrosine kinases is implicated in multiple distinct oncogenic signaling pathways. However, to date, there are no...

 

Coiled Coils

Price Lab

Reflecting recent work in the Price lab

Coiled coils are one of most common protein quaternary structures and represent the best understood relationship between amino acid sequence and protein...

 

Network Pharmacology

Jin Lab

Reflecting recent work in the Jin lab

Carapax Trionycis is a traditional Chinese medicine and it has been clear that oligo-peptides from Carapax Trionycis extract, CTP, are the main active substances...

 

Azobenzene Moiety

Wiedman Lab

Reflecting recent work in the Wiedman lab

Azobenzenes are a series of compounds that can be isomerized upon irradiation with light. These molecules can...

 

Monoclonal Antibodies

Nowick Lab

Reflecting recent work in the Nowick lab

Monoclonal antibodies, mAbs, that target the β-amyloid peptide, Aβ, are important Alzheimer's disease research tools and are now being...

 

Novel, Rational Drug Design

Deber Lab

Reflecting recent work in the Deber lab

As an alternative approach to conventional antibiotics, members of the Charles Deber laboratory, published in Peptide Science, explore a novel...

 

Bicyclic Peptides

Nitsche Lab

Reflecting recent work in the Nitsche lab

Bicyclic peptides have emerged as one of the driving forces within the constrained peptide family. Due to their unique pharmaceutical attributes...

 

Self-Sorting Collagen

Wennemers Lab

Reflecting recent work in the Wennemers lab

Nature uses elaborate methods to control protein assembly, including that of heterotrimeric collagen....

 

Lasso Peptides

Swanson Lab

Reflecting recent work in the Swanson lab

Lasso peptides make up a class of natural products characterized by a threaded structure. Given their small size and stability, chemical synthesis would offer tremendous potential...

 

Alzheimer’s Amyloid-β

Raskatov Lab

Reflecting recent work in the Raskatov lab

Amyloid aggregation is a key feature of Alzheimer's disease, AD, and a primary target for past and present therapeutic efforts. Recent research is making it increasingly clear...

 

Finding Pulmonary Fibrosis

Raines Lab

Reflecting recent work in the Raines lab

Idiopathic pulmonary fibrosis, IPF, is a disease of unknown etiology that is characterized by excessive deposition and abnormal remodeling of collagen...

 

N-Terminal Acetylation

Petersson Lab

Reflecting recent work in the Petersson lab

N-terminal acetylation is a chemical modification carried out by N-terminal acetyltransferases. A major member of this enzyme family, NatB, acts on much of the human proteome...

 

C–H Radiocyanation

Mapp Lab

Reflecting recent work in the Mapp and Sanford labs

In a collaborative work, published in Chemical Science, between the Mapp and Sanford groups, and researchers at the Department of Radiology, all at the University of Michigan, authors describe...

 

α-Helical Peptides

McGee Lab

Reflecting recent work from FOG Pharmaceuticals

Molecules that induce novel interactions between proteins hold great promise for the study of biological systems and the development of therapeutics, but their discovery...

 

Reversible Covalent Warheads

Gao Lab

Reflecting recent work in the Gao lab

Falling in between traditional small molecules and antibodies in size, peptides are emerging as a privileged therapeutic modality, one that can harness...

 

Max Phosphorylation

Jbara Lab

Reflecting recent work in the Jbara lab

The chemical synthesis of site-specifically modified transcription factors, TFs, is a powerful method to investigate how post-translational modifications influence TF-DNA...

 

Mechanistic Studies of CyClick Chemistry

Raj Lab

Reflecting recent work in the Raj and Houk labs

Macrocyclic peptides have become increasingly important in the pharmaceutical industry. In collaborative work between the groups of Kendall N. Houk and Monika Raj, published in...

 

Cytosolic Delivery of Functional Cargoes

Hackenberger Lab

Reflecting recent work in the Hackenberger lab

In research published in JACS, members of the Hackenberger Group, describe a powerful, simple, and highly effective strategy for the intracellular delivery...

 

SPAAC Reactions

Schneider Lab

Reflecting recent work in the Schneider lab

Joel P. Schneider, Yixin Xie, and Tania L. Lopez-Silva at the National Cancer Institute, report a new positively charged azidoamino acid for strain-promoted azide–alkyne cycloaddition...

 

Human Serum Albumin

Lam Lab

Reflecting recent work in the Lam lab

Human serum albumin, HSA, is the most abundant protein in human blood plasma. It plays a critical role in the native transportation of numerous drugs, metabolites, nutrients, and small molecules...

 

Tyrosine Phosphorylation

Hecht Lab

Reflecting recent work in the Hecht lab

The family of NF-κB transcriptional activators controls the expression of many genes, including those involved in cell survival and development. The family consists of...

 

Pargamicin A

Del Valle Lab

Reflecting recent work in the Del Valle lab

Researchers in the Del Valle Group, published in Organic Letters, report the total synthesis and configurational assignment of pargamicin A, a highly oxidized nonribosomal peptide...

 

Glycan Biology

Imperiali Lab

Reflecting recent work in the Imperiali lab

Glycan-binding proteins, GBPs, are widely used reagents for basic research and clinical applications. These reagents allow for the identification and manipulation of glycan determinants...

 

Drug Candidate

Nowick Lab

Reflecting recent work in the Nowick lab

In this article, published in Chemical Science, members of the James S. Nowick group show that the antibiotic teixobactin is a promising drug candidate...

 

Stereoselectivity

Wennemers Lab

Reflecting recent work in the Wennemers lab

In this article we show that stereoselective peptide catalysis is feasible in complex environments, including cell lysates...

 

Anticancer Protein

Bagheri Lab

Reflecting recent work in the Bagheri lab

Cancer is one of the leading causes of mortality in the world. Unfortunately, the present anticancer chemotherapeutics display high cytotoxicity...

 

Peptides and Proteins

Raines Lab

Reflecting recent work in the Raines lab

Transforming growth factor-β (TGF-β) plays important roles in wound healing. The activity of TGF-β is initiated upon the binding of the growth factor...

 

Cyclic Peptides

Heinis Lab

Reflecting recent work in the Heinis lab

The synthesis of large numbers of cyclic peptides─required, for example, in screens for drug development─is currently limited by the need of chromatographic...

 

Ribosomal synthesis

Suga Lab

Reflecting recent work in the Suga lab

Aromatic cyclic β2,3-amino acids (cβAAs), such as 2-aminobenzoic acid and 3-aminothiophene-2-carboxylic acid, are building blocks that can induce unique folding...

 

PKC Disruptors

Kennedy Lab

Reflecting recent work in the Kennedy lab

Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide array of signaling pathways and physiological processes...

 

“Imprint-and-Report” DCLs

Waters Lab

Reflecting recent work in the Waters lab

Sensor arrays using synthetic receptors have found great utility in analyte detection, resulting from their ability to distinguish analytes based on differential signals via...

 

Kinase inhibitors

Kennedy Lab

Reflecting recent work in the Kennedy lab

Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and GTPase function that is commonly mutated in both familial and idiopathic...

 

Protease Inhibitors

Petersson Lab

Reflecting recent work in the Petersson lab

Aberrant levels of cathepsin L (Cts L), a ubiquitously expressed endosomal cysteine protease, have been implicated in many diseases such as cancer and diabetes...

 

Antibacterial Hydrogels

Schneider Lab

Reflecting recent work in the Schneider lab

Herein, it is demonstrated that a peptide derived from mussel foot protein-5, a key protein in mussel adhesion, displays antibacterial properties, a yet unreported...

 

Protein Interactions

Pikaard Lab

Reflecting recent work in the Pikaard lab

In plants, transcription of selfish genetic elements such as transposons and DNA viruses is suppressed by RNA-directed DNA methylation...

 

Protein Mimic

Arora Lab

Reflecting recent work in the Arora lab

Members of the Arora lab constructed a synthetic Sos protein mimic that engages the wild-type and oncogenic forms of nucleotide-bound Ras and modulates downstream kinase signaling...

 

Rippled β-Sheet Motif

 Lab

Reflecting recent work in the lab

In this conspectus, the authors give an overview of the early history of the rippled β-sheet and provide a detailed structural description/definition of this motif...

 

Ion Channels

Woolfson Lab

Reflecting recent work in the Woolfson lab

The design of peptides that assemble in membranes to form functional ion channels is challenging. Specifically, hydrophobic interactions must be...

 

B-cell Epitope

Kaumaya Lab

Reflecting recent work in the Kaumaya lab

Herein, researchers in the Kaumaya lab describe a novel PD-1 B-cell peptide epitope vaccine (amino acid 92–110; PD1-Vaxx) linked to a measles virus fusion peptide...

 

Peptide Cancer Vaccines

 Lab

Reflecting recent work in the lab

In this article, Professor Pravin Kaumaya reviews his lab's approaches and strategies that focus on B-cell epitope cancer vaccines...

 

Production Technology

Schwarz Lab

Reflecting recent work in the Schwarz lab

The production of peptides as active pharmaceutical ingredients (APIs) by recombinant technologies is of emerging interest. A reliable production platform, however...

 

Protein Synthesis

Premdjee Lab

Reflecting recent work in the Premdjee lab

Chemical protein synthesis is a powerful avenue for accessing homogeneously modified proteins, but access to large targets has proved challenging...

 

Peptide Libraries

Derda Lab

Reflecting recent work in the Derda lab

Herein is described a divergent late-stage approach to generating macrocyclic peptide libraries with unnatural pharmacophores from readily available starting material...

 

Peptide Synthesis

Brik Lab

Reflecting recent work in the Brik lab

Despite six decades of efforts to synthesize peptides and proteins bearing multiple disulfide bonds, this synthetic challenge remains an unsolved problem...

 

Peptide-Based Vaccines

 Lab

Reflecting recent work in the lab

In this Review, the authors discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer’s disease, and cancer...

 

Stapled Peptides

Han Lab

Reflecting recent work in the Han lab

Diabetes is characterized by pancreas dysfunction and is commonly associated with obesity. Hypoglycemic agents capable of improving β-cell function...

 

Protein-Protein Interactions

Pomerantz Lab

Reflecting recent work in the Pomerantz lab

Herein is reported the first application of protein-observed fluorine (PrOF) NMR to the tandem bromodomains of BRD4 and BRDT to quantify the selectivity of their...

 

Lariat Peptides

Lokey Lab

Reflecting recent work in the Lokey lab

Many lariat peptide natural products exhibit interesting biological activities, and some, such as griselimycin and didemnin B, are membrane permeable...

 

Endosomal Escape

Futaki Lab

Reflecting recent work in the Futaki lab

Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies for endosomal cargo release...

 

Oxime Ligation

Burke Lab

Reflecting recent work in the Burke lab

The current review will focus on the authors’ use of peptide ligation to optimize PPI antagonists directed against several targets...

 

Tyr-Lock Peptide

O'Keefe Lab

Reflecting recent work in the O'Keefe lab

High-throughput screening for inhibitors of TDP1 activity resulted in the discovery of a new class of knotted cyclic peptides...

 

DNA nanotechnology

Seitz Lab

Reflecting recent work in the Seitz lab

DNA nanotechnology is an emerging field that promises fascinating opportunities for the manipulation and imaging of proteins on a cell surface...

 

Cyclic Peptide Ligands

Suga Lab

Reflecting recent work in the Suga lab

Herein is identified three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation−mRNA display selection platform...

 

Peptidomimetic Uptake

Arora Lab

Reflecting recent work in the Arora lab

Researchers in the Arora Lab observed that the cellular uptake of peptides is critically determined by the cell line-specifically, they noted that peptides show better uptake...

 

Antimicrobial Synergy

Raines Lab

Reflecting recent work in the Raines lab

Authors Chelcie Eller and Ron Raines find that human LL-37 and human RNase 1 can act synergistically to kill Gram-negative bacterial cells...

 

Social Media Guide

Heemstra​ Lab

Reflecting recent work in the Heemstra​ lab

An ACS editorial that provides scientists a guide to navigating and using social media to share ideas and enhance connections...

 

Membrane-Lytic Peptides

Schneider Lab

Reflecting recent work in the Schneider lab

Herein is described the use of peptide backbone N-methylation as a new strategy to transform membrane-lytic peptides (MLPs) into cytocompatible intracellular delivery vehicles...

 

Frog-skin Peptides

Craik Lab

Reflecting recent work in the Craik lab

In this study, the researchers investigated naturally occurring peptides derived from frog skin secretions for selectivity and activity toward melanocortin receptors...

 

Flow SPPS

Hartrampf Lab

Reflecting recent work in the Hartrampf lab

Flow‐based approaches to solid phase peptide synthesis (SPPS) have been pursued since the method's early days, with anticipated gains in...

 

Bioorthogonal Conjugation

Salmain Lab

Reflecting recent work in the Salmain lab

This minireview intends provides an up‐to‐date overview on the various bioorthogonal strategies implemented for the conjugation of transition organometallic entities...

 

Coronavirus Inhibitors

Hoffman Lab

Reflecting recent work in the Hoffman lab

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1...

 

Targeting Malaria

Kennedy Lab

Reflecting recent work in the Kennedy lab

Herein is a review of ongoing research aimed at developing constrained peptides targeting protein-protein interactions pertinent to malaria pathogenesis.

 

Disrupt Ubiquitination

Walensky Lab

Reflecting recent work in the Walensky lab

The ubiquitin–proteasome system (UPS) is a highly regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be an effective cancer treatment.

 

Cell Permeability

Verma Lab

Reflecting recent work in the Verma lab

In a larger collaborative effort, these researchers have combined the strategies to identify the first examples of all-D α-helical stapled and stitched peptides.

 

Stapled Peptide

Garner Lab

Reflecting recent work in the Garner lab

Eukaryotic translation initiation factor 4E (eIF4E) has emerged as a promising cancer therapeutic target due to its role in the initiation of cap-dependent translation...

 

Peptide Hydrogels

Schneider Lab

Reflecting recent work in the Schneider lab

Herein, a noninteracting multiphase molecular assembly approach is developed to crystallize tofacitinib, a potent JAK1/3 inhibitor, within a shearthinning self-assembled fibrillar peptide hydrogel network...

 

Antimicrobial Peptides

Church Lab

Reflecting recent work in the Church lab

Church et al. report a tunable chemical genetics approach for enhancing genetic code expansion in different wild-type bacterial strains..

 

Protein Stability

Chatterjee Lab

Reflecting recent work in the Chatterjee lab

Abundant n → π* interactions between adjacent backbone carbonyl groups are predicted to play an important role in dictating the structure of proteins...

 

Modified Amino Acids

Wang Lab

Reflecting recent work in the Wang lab

Herein, Wang et al. present a photoredox-catalyzed asymmetric method for the preparation of enantiopure β-thiolated/selenolated amino acids using a simple chiral auxiliary...

 

Mapping SARS-CoV-2

Ng Lab

Reflecting recent work in the Ng lab

Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of diagnostic tools...

 

COVID-19 Therapeutics

Yousef Lab

Reflecting recent work in the Yousef lab

In this review, the researchers summarize peptide and peptide based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...

 

Tyrosine Sulfation

Payne Lab

Reflecting recent work in the Payne lab

Researchers at the University of Sydney have shown that the evasin protein ACA-01 from the Amblyomma cajennense tick can be posttranslationally sulfated at two tyrosine residues...

 

Micelle-assisted Reactions

Devaraj Lab

Reflecting recent work in the Devaraj lab

This publication shows that micelle-assisted reaction can facilitate native chemical ligations between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety...

 

Chemical Protein Synthesis

Mandal Lab

Reflecting recent work in the Mandal lab

Herein is reported an operationally simple method to facilitate chemical protein synthesis by fully convergent and one-pot native chemical ligations...

 

Targeting GPCRs

Davenport Lab

Reflecting recent work in the Davenport lab

This recently published review discusses the current status of the peptide drugs targeting G protein-coupled receptors (GPCRs), with a focus on evolving strategies...

 

β-Turn Mimics

Thomson Lab

Reflecting recent work in the Thomson lab

Researchers report a simple reductive amination protocol to ligate two peptides, while simultaneously installing a β-turn mimic at the ligation junction...

 

Fluorescent Peptide

Nowick Lab

Reflecting recent work in the Nowick lab

Teixobactin is a nonribosomal antibiotic peptide that inhibits the biosynthesis of peptidoglycan and teichoic acid, however, teixobactin’s cellular site of action is unknown...

 

Constrained Peptides

Waldmann Lab

Reflecting recent work in the Waldmann lab

Guéret and colleagues describe a versatile method for inserting chiral motifs between the ends of omega loops. Peptides are synthesized using traditional SPPS...

 

Coupling Agent Hazards

Nowick Lab

Reflecting recent work in the Nowick lab

This case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, is a cautionary note for researchers who handle peptide coupling agents frequently...

 

Molecular Transporters

Parang Lab

Reflecting recent work in the Parang lab

In this collaborative study, researchers have designed a new generation of peptides based on previously designed cyclic cell-penetrating peptides. They have evaluated their cytotoxicity as well as uptake behavior...

 

C1B1 Inhibition

Pearce Lab

Reflecting recent work in the Pearce lab

In this recent publication, Puhl et al. have employed random peptide phage display to screen and select peptides that bind to the calcium and integrin binding protein 1 (CIB1)...

 

Aqueous SPPS

Kolmar Lab

Reflecting recent work in the Kolmar lab

The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly...

 

Cyclotide Uptake

Wang Lab

Reflecting recent work in the Wang lab

In this study, the recently developed chloroalkane penetration assay was combined with established assays to characterize the cellular uptake and cytosolic delivery of the prototypic cyclotide, kalata B1...

 

Cyclotide Production

Craik Lab

Reflecting recent work in the Craik lab

In this manuscript researchers in Dr. Craik's lab describe a strategy to improve the production of cyclotides, which are usually produced and cyclized synthetically at a high cost and environmental impact for large scale.

 

Improved Thiol Protection

Distefano Lab

Reflecting recent work in the Distefano lab

Photoremovable caging groups are useful for biological applications because the deprotection process can be initiated by illumination with light without the necessity of adding additional reagents...

 

Peptide Self Assembly

Montenegro Lab

Reflecting recent work in the Montenegro lab

Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes...

 

Peptide Mimics

Liu Lab

Reflecting recent work in the Liu lab

Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications...

 

γ-Amino Acids Elongation

Suga Lab

Reflecting recent work in the Suga lab

Because γ-amino acids generally undergo rapid self-cyclization upon esterification on the carboxyl group, for example, γ-aminoacyl-tRNA, there are no reports of the ribosomal elongation...

 

Nanosheet Fabrication

Conticello Lab

Reflecting recent work in the Conticello lab

Engineering free-standing 2D nanomaterials with compositional, spatial, and functional control across size regimes from the nano- to mesoscale represents a significant challenge....

 

Hydrophobic Moieties

Wennemers Lab

Reflecting recent work in the Wennemers lab

Trans amide bonds and fast cis–trans isomerization of Xaa-Pro bonds are crucial for the stability and folding rate of collagen, the most abundant protein in mammals...

 

Platinum Nanoparticles

Wennemers Lab

Reflecting recent work in the Wennemers lab

Hepatocellular carcinoma, HCC, is the sixth most frequent cancer and the second leading cause of death from cancer worldwide. Sorafenib is the most commonly used FDA‐approved systemic...

 

Ice Nucleators

Derda Lab

Reflecting recent work in the Derda lab

In a manuscript published in Langmuir, Yuki Kamijo and Ratmir Derda from the, University of Alberta, describe a screening system that employs the difference...

 

Ghost Peptides

Raines Lab

Reflecting recent work in the Raines lab

A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Published in ACS Chemical Biology, and presented...

 

Octreotide Analogs

Papini Lab

Reflecting recent work in the Papini lab

Somatostatin, SS, is a cyclic tetradecapeptide able to inhibit the release of growth hormone, GH, mainly through the binding to two G‐protein coupled...

 

Enzyme Sequestration

Xu Lab

Reflecting recent work in the Xu lab

Liquid-like droplets of biomacromolecules are emerging as a fundamental mechanism of cellular signaling, but designing synthetic mimics to form such...

 

Short Peptides

Arora Lab

Reflecting recent work in the Arora lab

Helical secondary and tertiary motifs are commonly observed as binding epitopes in natural and engineered protein scaffolds. While several strategies...

 

Roads to Rome

Schmidt Lab

Reflecting recent work in the Schmidt lab

Ribosomally synthesized and post-translationally modified peptides, RiPPs, are ubiquitous natural products. Bioactive RiPPs are produced from a precursor...

 

Azapeptide Libraries

Lubell Lab

Reflecting recent work in the Lubell lab

Aza‐propargylglycine, azaPra, peptides are branching points for the synthesis of azapeptide libraries. Researchers in the Lubell Lab, published in...

 

Unprotected Peptides

Yoshiya Lab

Reflecting recent work in the Yoshiya lab

Ring-closing metathesis, RCM, is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected...

 

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