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Bioorthogonal Conjugation

Reflecting recent work in the Salmain lab

The advent of bioorthogonal chemistry has revolutionized the common practices in protein bioconjugation and contributed to a large extent to the development of chemical biology, a discipline aimed at studying biological/biochemical processes/events in their natural setting, living cells, whole organisms, using dedicated chemical tools.

This minireview provides an up‐to‐date overview on the various bioorthogonal strategies implemented for the conjugation of transition organometallic entities to peptides, peptide nucleic acids and proteins with a focus on targeted applications, for example, fluorescence‐ or radio‐labeling for imaging, controlled delivery of therapeutic agents and bioanalysis.

Salmain Lab item

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