Peptide Publications Archive
Engineering Better Peptides
Bhunia Lab
More than 80 peptide drugs are approved worldwide, yet rapid proteolysis, poor oral bioavailability, and short plasma half-life still limit the class. A sweeping new …
Unexpected Biaryl Rings
Xu Lab
Glycopeptide antibiotics owe their potency to a precise architecture of biaryl cross-links, but the full repertoire of those cross-links was thought to be known. Targeted …
Mussel-Inspired Batteries
Wooley Lab
Catechol-bearing polypeptides built entirely from natural feedstocks can double as redox-active electrode materials and mussel-inspired binders, but getting the catechol density right proved decisive. Researchers …
Tuning the Antigen
Pires Lab
Peptide-based cancer vaccines aim to train the immune system against tumor-specific neoantigens, and a growing share of those targets comes from post-translational modifications rather than …
Light-Forged Macrocycles
Scanlan & Muttenthaler Labs
A photochemical thiol–yne reaction cyclizes neuropeptides under mild conditions, swapping the vulnerable disulfide bridge for a stable vinyl sulfide. One resulting oxytocin analogue proves more …
Folding the Sheet
Cai Lab
β-hairpins underpin protein recognition, amyloid assembly, and enzyme catalysis, yet engineering stable β-sheet mimics in small peptides remains stubbornly difficult. A new class of sulfonyl-modified …
Stability Meets Breadth
Koksch Lab
Antibiotic-resistant pathogens are outpacing conventional drugs, but antimicrobial peptides offer a structural solution. By swapping L-amino acids for their D-enantiomers and adding a pentafluorinated residue, …
Mirror Cargo Uptake
Brik Lab
D-amino acid proteins resist proteolytic degradation and are prized as therapeutic scaffolds, yet a fundamental question has lingered: do mirror-image cargos enter cells as readily …
Nucleopeptides Fight Resistance
Banerjee Lab
A set of thymine-conjugated nucleopeptides, engineered with fatty acyl chains of varying length at the C-terminus, self-assembles into nanofibers and kills multidrug-resistant bacteria and fungi …
Parasite-Derived Defenders
Cardoso Lab
A protein fragment from the malaria parasite Plasmodium chabaudi holds little obvious therapeutic promise, yet a computational algorithm turned it into three peptides that disrupt …
Greener Peptide Production
Payne Lab
Solid-phase peptide synthesis generates enormous chemical waste and struggles beyond roughly 50 residues. A new tag-assisted ligation strategy couples aryl selenoesters to side-chain-protected fragments in …
Chirality Switches Piezoelectricity
Ghosh Lab
A pyrene-conjugated tetrapeptide assembles into nanofibers that are both chirally silent and piezoelectrically inert in pure water, yet adding just 1% DMSO flips a supramolecular …
Bifunctional Peptide Oxidation
Miller Lab
Axially chiral biaryl aldehydes are prized scaffolds in medicinal chemistry and asymmetric catalysis, yet enantioselective aerobic oxidations to access them have remained elusive. A new …
Wnt5a Competitor
Suga Lab
Diffuse intrinsic pontine glioma, DIPG, kills most children within two years of diagnosis and resists virtually every treatment tried so far. Now, a macrocyclic peptide …
Integrity Shapes Selection
Hampton and Liu labs
When a protein target is tethered to a solid support for phage display, does the immobilization chemistry matter? Researchers at Texas A&M engineered three structurally …
Ribosome Peptide Mining
Kurkcuoglu Lab
The bacterial ribosome is a proven antibiotic target, yet peptide-based modulation of its allosteric machinery remains largely uncharted. A new multiscale computational pipeline screens thousands …
Peptide Reveals Oligomers
Gandy, Arancio, Ehrlich, Guérin, Lubell, and Rahimipour Labs
A multi-institutional team supervised jointly by Sam Gandy, Ottavio Arancio, and Michelle Ehrlich, published in Alzheimer's Dement., turned a designed cyclic D,L-α-peptide into a …
Locking Out RAS
Therrien Lab
Resistance to approved RAS inhibitors emerges rapidly in patients, driven by secondary mutations at the Switch-II and cyclophilin-A binding pockets. A team at Université de …
GLP-1s Block Amyloid
Limbocker Lab
Millions of people already take GLP-1 receptor agonists for diabetes and weight loss, but whether these drugs directly interfere with the molecular machinery of Alzheimer's …
Profiling Transpeptidase Targets
Pires Lab
Tuberculosis kills more than a million people each year, yet the enzymes that stitch together its cell wall remain poorly understood and difficult to target. …
Steering Cysteine Chemistry
Tsai Lab
Most reagents that target N-terminal cysteine consume both the amine and thiol, locking the ligation site into an inert heterocycle. A new steric-control strategy forces …
Paired Library Pursuit
Suga Lab
Most peptide discovery platforms find one binder at a time. A new library-vs-library extension of the RaPID system pairs two 10¹²-member macrocyclic peptide libraries and …
Hydrazino Turn Hunters
Suga Lab
α-Hydrazino acids have long tantalized peptide chemists with their turn-inducing and protease-resisting properties, yet no one had managed to screen them de novo against protein …
Backbone Heteroatom Shield
Del Valle Lab
Replacing backbone amide nitrogens with nitrogen or oxygen heteroatoms can slow protease degradation without sacrificing the folded structures peptides need to work. A tetra-N-aminated antimicrobial …