Peptide Publications Archive
Showing items in Cyclic Peptides · Clear filter
Choosing Conformations
Yudin Lab
Macrocyclic peptides can fold into multiple conformations, but chemists have lacked a reliable chemical handle for selecting one over another. A late-stage lactone-opening reaction now …
Cycling on Bacteria
Tharp Lab
Cell-surface display of cyclic peptide libraries offers a fluorescence-sortable alternative to phage display, but generating stable macrocycles directly on living bacteria has resisted clean, bioorthogonal …
Electrochemical Biaryl Stapling
Hugh Nakamura Lab
Biaryl-bridged cyclic peptides from ribosomally synthesized and post-translationally modified peptides offer compelling drug-like properties, yet their rigid ring systems have made systematic analog synthesis almost …
Boronic Glycan Hunters
Suga Lab
Glycans drive cancer progression yet resist the synthetic binders that proteins attract so readily. A new platform combining genetic code reprogramming with mRNA display now …
Tuning Integrin Selectivity
Wang and Hu Lab
RGD peptides have long struggled to distinguish between closely related integrin subtypes, limiting their diagnostic precision. A new conformational tuning strategy, varying cross-linker length and …
Aldehyde Backbone Bending
Suga Lab
α-Amino-γ-lactam residues impose backbone constraints that can boost membrane permeability, yet no method existed for installing them post-translationally inside a display system. Now, an aldehyde-triggered …
Stapling With PMDA
Zhang and Li Groups
Peptide stapling typically demands exotic amino acids, cysteine handles, or metal catalysts, each carrying trade-offs in selectivity or modularity. A new pyromellitic dianhydride linker sidesteps …
Mushroom Toxins Decoded
Süssmuth Lab
Cortinarins are bicyclic peptides from toxic Cortinarius mushrooms that have resisted independent biological study for decades. A new total synthesis now unlocks milligram quantities of …
Tricycles from Display
Jongkees Lab
Tricyclic peptides offer tighter binding, better selectivity, and longer serum lifetimes than simpler macrocycles, but generating single regioisomers at the high dilution of mRNA display …
Light-Forged Macrocycles
Scanlan & Muttenthaler Labs
A photochemical thiol–yne reaction cyclizes neuropeptides under mild conditions, swapping the vulnerable disulfide bridge for a stable vinyl sulfide. One resulting oxytocin analogue proves more …
Wnt5a Competitor
Suga Lab
Diffuse intrinsic pontine glioma, DIPG, kills most children within two years of diagnosis and resists virtually every treatment tried so far. Now, a macrocyclic peptide …
Integrity Shapes Selection
Hampton and Liu labs
When a protein target is tethered to a solid support for phage display, does the immobilization chemistry matter? Researchers at Texas A&M engineered three structurally …
Peptide Reveals Oligomers
Gandy, Arancio, Ehrlich, Guérin, Lubell, and Rahimipour Labs
A multi-institutional team supervised jointly by Sam Gandy, Ottavio Arancio, and Michelle Ehrlich, published in Alzheimer's Dement., turned a designed cyclic D,L-α-peptide into a …
Locking Out RAS
Therrien Lab
Resistance to approved RAS inhibitors emerges rapidly in patients, driven by secondary mutations at the Switch-II and cyclophilin-A binding pockets. A team at Université de …
Yeast Finds Inhibitors
Angelini Lab
Yeast display technology, long used to evolve antibodies, can now rapidly surface macrocyclic peptide inhibitors of human angiotensin-converting enzyme 2 with potencies in the low-nanomolar …
Chameleonic Proline Rings
Palma Lab
A new family of all-peptide macrocycles built from alternating L- and D-proline tetramers flips between two distinct conformations depending on solvent, solves long-standing functionalization challenges …
Ansamers Target Integrins
Yao Lab
Bicyclic peptides derived from the amanitin scaffold can exist as non-interconvertible conformational isomers called ansamers, and the two mirror-like forms can differ by orders of …
Scalable Azapeptide Macrocycles
Lubell Lab
A convergent solution-phase strategy for a potent macrocyclic azapeptide CD36 modulator sidesteps preparative chromatography entirely, delivering 100 mg of >99%-pure material by swapping an oligomer-prone …
Activating Native Termini
Raj Lab
Thiazoline and thiazole macrocycles embedded in bioactive marine peptides have long required pre-built specialty building blocks that slow synthesis and risk epimerization. A new palladium-mediated …
Hunting Huntingtin
Harding Lab
Huntingtin, the protein at the center of Huntington's disease, has long resisted selective chemical interrogation. A new suite of macrocyclic peptide tools now binds it …
Unlocking Small Macrocycles
VanVeller Lab
Short homochiral peptides routinely defeat macrocyclization attempts, either failing to close the ring or dissolving poorly enough to prevent even trying. A single backbone thioimidate …
Cornering RhoA G17V
Liu-Hampton Lab
RhoA G17V drives nearly 70% of angioimmunoblastic T-cell lymphoma cases yet has resisted every small-molecule effort for decades. Now, a phage-displayed macrocyclic peptide library yields …
Function-First Macrocycles
Suga Lab
A new cell-based mRNA display platform bypasses affinity-only screening to discover a macrocyclic insulin receptor agonist that conventional methods would have missed...
Bismuth Bicycles
Spring Group & Bicycle Therapeutics
Researchers in the Spring Group at the University of Cambridge, working in collaboration with Bicycle Therapeutics, explored bismuth(III) as an alternative scaffold for bicyclic peptide …