Peptide Publications Archive
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Assembling Retroaldolases
Korendovych Lab
Designing enzymes from scratch is hard; nature took billions of years to do it. A new study shows that short peptides can spontaneously self-assemble into …
Fluorinated Core Evolution
Suga Lab
Protein hydrophobic cores packed almost entirely with fluorinated amino acids were thought to be incompatible with defined biological function. A new selection platform challenged that …
Glycine Builds Collagen
Raines Lab
The collagen triple helix is nature's most abundant protein fold, yet chemists have long assumed it requires proline and hydroxyproline to form. New work shows …
Lysine Covalent Capture
Baker Group
Cysteine-targeting covalent warheads dominate drug design, yet cysteine is the rarest amino acid in proteins and nearly absent from protein-protein interfaces. A new lysine-reactive chemistry …
Painting Amyloid
Rüdiger and Friedler labs
Amyloid fibrils in Alzheimer's and Huntington's disease desperately need better molecular tools, yet most peptide scaffolds offer little chemical flexibility. A new modular peptide family …
Designing Molecular Switches
Baker Lab
Chemically induced dimerization systems give researchers on/off control over cellular processes, but existing tools borrow from nature and carry off-target liabilities. A new approach builds …
Blocking MS Autoantibodies
Kumar Lab
Current multiple sclerosis therapies suppress broad immune cell populations rather than the disease-specific autoantibodies that drive myelin destruction. A new computationally designed cyclic peptide targets …
Loop Surprise
Faure & Taillefumier Lab
Peptoids are celebrated for their helical folds, but a serendipitous discovery has revealed that hexamers with free termini can instead curl into a stable looplike …
Steric Backbone Advantage
Morimoto & Sando Lab
N-alkyl peptides cross cell membranes with unusual efficiency, and removing their amide hydrogens has long been credited as the reason why. A new study isolates …
Aziridines by Metallopeptide
Miller Lab
Aziridines are prized synthetic building blocks, yet making them enantioselectively from open-chain Z-disubstituted alkenes has long resisted reliable catalyst design. A new dirhodium metallopeptide system …
Switching Foldamer Helices
Legrand Lab
Foldamer chemists have long sought a simple switch to redirect backbone folding between distinct helical states. A French research team shows that permuting or substituting …
Condensate Surface Surfers
Arosio Lab
Biomolecular condensate interfaces drive protein aggregation and redox reactions, yet no general strategy existed for designing short peptides that park specifically at that boundary rather …
Locking the Helix
Wendeborn and Shahgaldian Groups
Short peptides rarely hold their α-helical shape at physiological temperatures, which limits their use in nanomaterial interfaces. A covalent surface-chemistry strategy on silica nanoparticles not …
Protein Space Illuminated
DeGrado Lab
How often does a random sequence fold into a stable protein? Surprisingly often, if that sequence repeats itself. A large-scale computational survey of tandem-repeat proteins …
Foldamers in Membranes
Clayden Lab
Synthetic foldamers that switch their internal hydrogen-bond direction could one day carry signals across cell membranes, but only if their conformational dynamics survive the lipid …
Groovy Foldamer Design
Huc Lab
Aromatic foldamers that mimic DNA can already outcompete the double helix for binding certain proteins, but their repetitive structure limits sequence-specific recognition. Now, four new …
Phosphorylation Mimics Hydroxylation
Raines Lab
Collagen stability depends on 4-hydroxyproline, a permanent modification. Now, researchers show that phosphorylation of threonine at the Yaa position of a collagen triple helix mimics …
Coiled-Coil Grafting
Wilson, Woolfson, and Itzhaki Groups
Protein–protein interactions are notoriously difficult to drug, but coiled-coil peptides offer a structured scaffold for presenting binding hot spots. Researchers grafted p53 hot-spot residues onto …
Folding the Sheet
Cai Lab
β-hairpins underpin protein recognition, amyloid assembly, and enzyme catalysis, yet engineering stable β-sheet mimics in small peptides remains stubbornly difficult. A new class of sulfonyl-modified …
Bifunctional Peptide Oxidation
Miller Lab
Axially chiral biaryl aldehydes are prized scaffolds in medicinal chemistry and asymmetric catalysis, yet enantioselective aerobic oxidations to access them have remained elusive. A new …
Backbone Heteroatom Shield
Del Valle Lab
Replacing backbone amide nitrogens with nitrogen or oxygen heteroatoms can slow protease degradation without sacrificing the folded structures peptides need to work. A tetra-N-aminated antimicrobial …
Linkers Shape Collagen
Merg Lab
Covalently tethered collagen-mimetic peptides fold into triple helices and assemble into nanosheets, but how does the linker connecting each strand to its scaffold influence stability? …
Coaxing New Vessels
Choi Lab
An AI-designed peptide mimics VEGF's receptor-activating power, accelerating wound closure in diabetic mice and raising hopes for a stable, tunable pro-angiogenic therapy
Engineering Disorder
Horne Group
Researchers in the Horne Group at the University of Pittsburgh, published in Biochemistry, set out to develop a systematic method for manipulating the unfolded …