APS Knowledge Base
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Introduction to Peptide Science
- Peptide Bond Formation: Mechanism and Energetics
- Hierarchical Structure of Peptides
- Peptide Function and Stability
- Early Discoveries and Key Figures
- Landmark Discoveries in Peptide Therapeutics
- Peptide Length and Nomenclature
- Post-Translational Modifications, PTMs
- Peptide Bond Fomation, Mechanism, and Energetics II
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Peptide Chemistry
- Mechanisms of Amide Bond Formation
- Protecting Groups - Strategy and Optimization
- Acid-Base Properties of Amino Acids
- Amino Acid Side Chains and Reactivity
- Chirality and Enantiomeric Purity in Peptides
- Peptide Chain Elongation: Efficiency and Challenges
- Fmoc vs. Boc Strategies
- Advances in SPPS: Automated Synthesis
- Comparison with SPPS: Benefits and Limitations
- Solution-Phase Peptide Coupling Reagents
- Integration of Solid and Liquid Phases
- Emerging Methods in Peptide Synthesis
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Peptide Biology
- Peptides in Cell Signaling - Receptors and Pathways
- Peptide-Protein Interactions - Mechanisms and Affinity
- Peptide Hormones and Neurotransmitters
- Antimicrobial Peptides, AMPs, - Mechanisms and Function
- Peptide Antigens in Immune Responses
- Role of Peptides in Autoimmunity and Vaccines
- Peptide Morphogens and Tissue Patterning
- Growth Factors - Mechanism of Action and Signaling Pathways
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Analytical Techniques
- Principles of Peptide Ionization - ESI & MALDI
- Tandem Mass Spectrometry - MS/MS - for Peptide Sequencing
- Quantitative Mass Spectrometry Techniques
- 1D and 2D NMR Techniques for Peptide Structure Elucidation
- Isotopic Labeling for High-Resolution NMR
- Reverse-Phase HPLC for Peptide Purification
- Gas Chromatography for Peptides - Applications and Limitations
- CD in Analyzing Peptide Secondary Structure
- Applications in Folding and Stability Studies
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Peptide Design and Engineering
- Structure-Activity Relationship, SAR, in Peptides
- Designing Peptides for Stability and Target Specificity
- Backbone Modifications for Increased Stability
- Small Molecule Peptide Mimetics
- Combinatorial Peptide Libraries: Synthesis and Applications
- High-Throughput Screening for Functional Peptides
- Molecular Dynamics Simulations for Peptide Folding
- In Silico Peptide-Protein Docking Studies
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Therapeutic Peptides
- Peptide-Based Enzyme Inhibitors
- Peptide-Drug Conjugates - PDCs
- Mechanisms of Action Against Pathogens
- Resistance Mechanisms and Overcoming Strategies
- Design and Development of Epitope-Based Vaccines
- Adjuvants and Delivery Systems for Peptide Vaccines
- Peptide Receptor Targeting in Cancer Therapy
- Peptides as Anti-Angiogenic Agents
- Venom Peptides from Terrestrial Species
- Venom Peptides from Oceanic Species
- Therapeutic Potential and Challenges
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Peptides in Materials Science
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Peptide Research Techniques
- Advanced Chromatographic Techniques for Peptides
- Crystallization Techniques for Structural Analysis
- X-ray Crystallography of Peptides
- Cryo-Electron Microscopy for Peptide Complexes
- Enzyme Kinetics and Peptide Inhibition Studies
- Cell-Based Assays for Peptide Activity
- Fluorescent and Bioluminescent Tagging of Peptides
- Peptides in In Vivo Imaging and Diagnostics
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Peptide Applications