Peptide Publications Archive
Cyclic Cell Anchors
Yamada Group
Researchers in the Kikkawa Group at Tokyo University of Pharmacy and Life Sciences, published in Biochemistry, have systematically characterized LDV-derived peptides as cell-adhesive molecules …
Supra-Bivalent Inhibitors
Sengoku and Suga Labs
A collaboration between the laboratories of Professor Hiroaki Suga at the University of Tokyo and Professor Toru Sengoku at Yokohama City University has developed a …
Mirrored for Stability
Luo Lab
T-cell immunoglobulin and mucin domain 3, TIM-3, ranks among the most promising immune checkpoint targets in oncology. Expressed on exhausted T cells, natural killer cells, …
Cysteine Boronation
Bandyopadhyay Lab
Boronic acids have earned a versatile reputation in chemical biology and drug design. Their empty p orbital allows dynamic switching between sp2 and sp …
Tryptophan N-Sulfenylation
Yuan Lab
Peptides have become increasingly important as drug candidates and research tools due to their favorable safety profiles and ability to modulate protein-protein interactions. However, native …
Targeted Evolution
Jumi Shin Lab
Rational protein design can create remarkable molecules, but it explores only a sliver of sequence space. The Shin group at the University of Toronto has …
Cytosolic Delivery
Beck-Sickinger Lab
Therapeutic peptides offer a powerful strategy for disrupting intracellular protein-protein interactions that small molecules cannot effectively target. However, delivering peptides to the cytosol presents a …
Oxytocin Receptor Imaging
Wuest Lab
Breast cancer remains a leading cause of cancer-related death worldwide, with tumor heterogeneity and absent biomarkers limiting diagnostic and therapeutic options. While PET tracers targeting …
Programmable Peptide Coacervates
Tian Lab
Peptide-based coacervates have emerged as versatile platforms for drug delivery, tissue scaffolding, bioreactor systems, and cellular regulation due to their sequence programmability, dynamic self-assembly, and …
Conditional Miniprotein Activation
Oller-Salvia Lab
Protein therapeutics have transformed treatment of diseases from cancer to immune disorders, yet many targets appear not only at diseased sites but also in healthy …
Chiral Prodrug Synthesis
Kong Lab
Carboxylic acid groups frequently serve as essential pharmacophores in drug molecules, yet their high polarity limits membrane permeability and can reduce bioavailability. Prodrug strategies address …
Computational Peptide Design
Guo Group
Xanthine oxidase catalyzes the final steps of purine catabolism, converting hypoxanthine and xanthine to uric acid. Dysregulation of this enzyme leads to excessive uric acid …
ACE-Inhibitory Peptides
Beys-da-Silva Lab
Hypertension remains the leading cause of premature death worldwide, yet one in five affected adults achieve adequate blood pressure control. Angiotensin-converting enzyme inhibitors represent one …
Nitrogen Walks
Huang/Xiao Labs
Noncanonical amino acids have become indispensable tools in chemical biology and drug discovery. By introducing side chains that nature never encoded, researchers can endow peptides …
Beyond Alpha
Ohshima/Yazaki Labs
Unnatural amino acids have transformed both medicinal chemistry and chemical biology. By introducing side chains that nature never encoded, chemists can enhance metabolic stability, tune …
Clicking Safely
Jain Lab
The 1,2,3-triazole ring has become indispensable in peptidomimetic design. Its geometry and electronic properties closely mimic the trans-amide bond: similar planarity, comparable dipole moment, and …
Catching Lanthanides
Zeymer Lab
Lanthanide ions offer an extraordinary toolkit for biomolecular engineering. Their long-lived luminescence enables sensitive detection, their paramagnetism provides NMR structural probes, their strong anomalous X-ray …
Designing Droplets
Pina Lab
Cells organize their interiors not only with membranes but also through liquid-liquid phase separation, LLPS, the spontaneous demixing that creates membraneless organelles like nucleoli and …
Binders by Design
Pomplun Lab
Discovering high-affinity ligands directly from protein structures has long tantalized drug discovery scientists. Virtual screening can explore billions of small molecules computationally, yet hit rates …
Ribosomal Bicycles
Suga Lab
Bicyclic peptides occupy a sweet spot in drug discovery. Their constrained architectures resist proteolytic degradation and bind targets with antibody-like specificity, yet they remain small …
Taming Aggregation
Hartrampf Lab
Peptide chains misbehave. During solid-phase peptide synthesis, growing chains can collapse into sticky β-sheet structures that clog the resin, block coupling reactions, and leave chemists …
NRPS Golden Gate
Bode Lab
A modular Golden Gate–based workflow unites the XUT concept with non-ribosomal peptide synthetase engineering, enabling rapid, scarless assembly of hybrid enzymes. Over 100 constructs yielded …
Mirror-Image Hunters
Denisov/Dijkgraaf Labs
Chemokines make frustrating drug targets. These small signaling proteins orchestrate immune cell migration during inflammation, making them attractive therapeutic targets for conditions ranging from atherosclerosis …
Luminescent Nanosheets
Granja/Montenegro Labs
Two-dimensional materials have captivated researchers since graphene's isolation in 2004, offering properties unmatched by their bulk counterparts. High surface areas, tunable electronics, and morphological anisotropy …