Peptide Publications Archive
Backbone Sensitivity
Cryle Lab
Researchers supervised by Professors Julien Tailhades and Max J. Cryle from Monash University, Australia, published in ACS Chemical Biology, have developed a chemoenzymatic strategy …
NMR Double Agent
Liu Lab
Researchers in the Liu Group at the Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, published in J. Am. Chem. Soc. …
Peptides Deliver Fluoride
Gouverneur Lab
Fluorine is among the most consequential substituents in medicinal chemistry, improving metabolic stability, membrane permeability, and target binding across a broad range of drug candidates
Unwinding RNA Delivery
Dulin Lab
Researchers in the Dulin Group at Vrije Universiteit Amsterdam investigated the biophysical effects of two peptides derived from the tomato aspermy virus 2b, TAV2b, protein …
Convergent Bradykinin Mimicry
Robinson Lab
Researchers in the Robinson Group at the University of Queensland, published in Science, demonstrated that bradykinin-like peptides found in hymenopteran venoms and anuran skin …
Site-Free Ligation
Hua Fu Lab
Researchers in the Fu Group at Tsinghua University in Beijing, published in Org. Lett., have developed a new chemoselective peptide ligation strategy, hydroxylamine-involved ligation, …
Jujube Unlocked
Kersten Lab
Researchers in the Kersten Group at the University of Michigan, published in J. Am. Chem. Soc., identified candidate biosynthetic genes in the genome of …
Intracellular Peptide Stapling
Mason Lab
Researchers in the Mason Group at the University of Bath, published in Cell Chemical Biology, developed a platform called intracellular-cyclization TBS that merges chemical …
Safety Catch Strategy
Albericio Lab
Researchers supervised by Professor Fernando Albericio at the University of KwaZulu-Natal developed a new family of safety-catch protecting groups based on the phenylthioethyl, Pte, and …
Ginkgo Degrader
Tam Lab
Researchers in the Tam Group at Nanyang Technological University identified a hyperdisulfide-constrained peptide from Ginkgo biloba nuts, termed β-ginkgotide β-gB1, as a first-in-class
Frankenproteins Block Myc
Shin Lab
The proto-oncogene MYC is dysregulated in more than 70% of human cancers and drives some of the most aggressive subtypes of breast cancer. Triple-negative breast …
Lasso Peptide Progress
Craik Lab
In a new Perspective published in the Journal of the American Chemical Society, Professor David J. Craik and colleagues at the University of Queensland's …
Barrier Shuttle Peptides
Norton Lab
Researchers supervised by Professor Raymond S. Norton at Monash University, Australia, published in the International Journal of Peptide Research and Therapeutics, developed a modular …
Targeted Fusion Inhibitors
Cheloha Lab
Researchers in the Cheloha Group at the National Institutes of Health, published in the Journal of the American Chemical Society, have developed nanobody-fusion inhibitor …
Programmable Hydrogel Mechanics
Pashuck Lab
Researchers in the Pashuck Group at Lehigh University, published in the Journal of the American Chemical Society, developed a modular approach that harnesses self-assembling …
Hemostatic Protein Polymers
Nash Group
Researchers supervised by Professor Michael A. Nash at the University of Basel, published in the Journal of the American Chemical Society, engineered a library …
Remote Stereocontrol
Miller Lab
Researchers in the Miller Group at Yale University, published in the Journal of the American Chemical Society, have developed guanidinylated peptide ligands that enable …
Mimicking Nature's Grip
Mott and Owen Lab
Researchers supervised by Drs. Helen Mott and Darerca Owen at the University of Cambridge, published in Biochemistry, engineered a new generation of disulfide-cyclized peptide …
Ready-Made Amino Acids
Liming Zhang Lab
Researchers in the Zhang Group at the University of California, Santa Barbara, published in the Journal of the American Chemical Society, developed a concise …
Cooperativity Unlocked
Waters Lab
Christopher Travis, and colleagues in Marcey Waters' laboratory at the University of North Carolina, published in Biochemistry, devised an elegant strategy to probe why …
Targeting Protein Interactions
Arora Lab
Researchers in the Arora Group at New York University, published in Chemical Reviews, have assembled a comprehensive blueprint for designing inhibitors of protein-protein interactions. …
Metabolic Resilience
Labs at Genentech
Researchers at Genentech, published in the Journal of Medicinal Chemistry, present a comprehensive perspective on the strategies that medicinal chemists and DMPK scientists now …
Green Peptide Synthesis
Wellings, Meldal, and Wade Groups
Researchers supervised by Dr. Donald A. Wellings, Nobel Laureate Professor Morten Meldal, and Professor John D. Wade at the University of Melbourne, published in Nature …
Tetrapeptide Cyclase
Parkinson Lab
Cyclic tetrapeptides occupy a tantalizing corner of chemical space. Head-to-tail macrocyclization eliminates the charged termini that limit membrane permeability, while the constrained