Peptide Publications Archive
Folding by Assembly
Nguyen Lab
Proteins need dozens to hundreds of amino acids to fold into functional three-dimensional shapes. A new porous framework strategy coaxes peptides of only 15 to …
Beyond Nature's Blueprint
Sharma, VanVeller, and Jain Labs
Macrocyclic peptides hold enormous therapeutic promise, but achieving oral bioavailability, membrane permeability, and metabolic stability simultaneously remains an unsolved puzzle. A new review surveys how …
Sactionine on Resin
Malins Lab
Enteropeptins are a newly described family of sactipeptides from a gut microbe, but their thiomorpholine core had resisted solid-phase assembly. A preformed acyclic building block …
Dual Cytokine Lock
Fetse Lab
IL-4 and IL-13 drive allergic and inflammatory disease through overlapping but distinct receptor interfaces, and no small peptide had been shown to block both pathways …
Wiring Covalent Libraries
Pentelute Lab & the Nile Lab at Calico Life Sciences
Peptide-encoded libraries can survey vast chemical space, but equipping them with covalent warheads has remained out of reach. A new on-resin Heck coupling platform threads …
Gels That Catalyze
Unciti-Broceta Lab
Palladium nanoparticles can activate prodrugs inside tumors, but previous metallogels lacked the mechanical properties and catalytic durability needed to reach animal studies. A new hybrid …
Backbone Without Borders
VanVeller Lab
Native peptide bonds lock nearly all their population into the trans configuration, making short-peptide cyclization a persistent low-yield problem. A new study finds that methyl …
Coral's Hidden Arsenal
Brötz-Oesterhelt, Costa, and Piel Groups
The marine bacterial genus Aquimarina harbors rich biosynthetic potential, yet almost none of its predicted natural products have ever been characterized. A new lipopeptide class …
Locking Peptide Shape
Spring and Yudin Labs
Macrocyclic peptides fold into multiple conformations, frustrating efforts to fix their three-dimensional shape. A new rhodium-catalyzed strategy now builds a biaryl "dominant rotor" directly into …
Lasso Peptide Surgery
Chu Lab
Lasso peptides are mechanically interlocked natural products whose knotted topology has made them resistant to chemical editing. A new chemoenzymatic strategy cuts and re-seals the …
Lattice by Sequence
Weil Lab
Peptide self-assembly has long relied on lengthy sequences or external scaffolds to achieve ordered porous architectures. Now, researchers show that a nine-residue peptide alone can …
Assembling Retroaldolases
Korendovych Lab
Designing enzymes from scratch is hard; nature took billions of years to do it. A new study shows that short peptides can spontaneously self-assemble into …
Fluorinated Core Evolution
Suga Lab
Protein hydrophobic cores packed almost entirely with fluorinated amino acids were thought to be incompatible with defined biological function. A new selection platform challenged that …
Minimal CSP Scaffolds
Tal-Gan Lab
Quorum sensing in Streptococcus sinensis depends on a competence-stimulating peptide whose minimum functional requirements were completely unknown. Reverse alanine scanning now reveals that nearly one-third …
SuFEx Locks Rings
Fan and Mi Teams
Metal-free macrocyclization has long been a bottleneck for DNA-encoded peptide libraries. A new SuFEx-based strategy closes rings in aqueous buffer within minutes, scales to 343 …
Glycine Builds Collagen
Raines Lab
The collagen triple helix is nature's most abundant protein fold, yet chemists have long assumed it requires proline and hydroxyproline to form. New work shows …
Blue-Light Uncaging
Banghart Lab
One-photon photopharmacology in the brain has long depended on UV or violet light, with its poor tissue penetration and phototoxicity concerns. A new caged opioid …
Pairing for Scale
Heinis Lab
Chemical peptide libraries in microwell plates have rarely exceeded a few thousand members, leaving a vast chemical space unreachable by functional screening. A disulfide-pairing strategy …
Pocket Engineering Polymyxin
Kries Lab
Polymyxin antibiotics save lives but cause kidney damage and face rising resistance. A single amino acid substitution in a biosynthetic enzyme now enables direct fermentative …
Tryptophan Quenches All
Vendrell Lab
Fluorogenic amino acids that span the full visible spectrum could transform wash-free cell imaging and drug screening, but no single intramolecular quenching motif had proven …
Lysine Covalent Capture
Baker Group
Cysteine-targeting covalent warheads dominate drug design, yet cysteine is the rarest amino acid in proteins and nearly absent from protein-protein interfaces. A new lysine-reactive chemistry …
Atomic Edits, Altered Assemblies
Conticello Lab
Swapping a single atom in a self-assembling peptide sequence can reshape the entire supramolecular architecture, even when the resulting filaments look nearly identical under a …
Disulfide Architecture Decoded
Raj Lab
Disulfide bonds in peptides are typically treated as chemically identical, forcing chemists to reduce them all before making any modification. A new architecture-guided approach reveals …
Azapeptides on Autopilot
Proulx Lab
Aza-amino acid substitutions can lock bioactive conformations and resist proteases, but the chemistry that builds them has stubbornly resisted automation. A new protocol adapts every …