Peptide Publications Archive
Threading Peptide Sequences
Dekker & Albada Labs
Researchers in the Dekker Group at Delft University of Technology, in collaboration with Bauke Albada at Wageningen University, published in the Journal of the American …
Frankenprotein Precision
Shin Lab
Researchers in the Shin Group at Chapman University, published in ACS Synthetic Biology, drew inspiration from an unusual source: the homeodomain-leucine zipper transcription factor …
Bacterial Crosstalk
Bertucci & Tal-Gan Labs
In a study published in ACS Infectious Diseases, researchers from the Tal Gan Group at the University of Nevada at Reno, and The Bertucci …
Helical Peptide Discovery
Suga and Katoh Labs
A team led by Hiroaki Suga and Takayuki Katoh at the University of Tokyo extended their engineered tRNA system, tRNAPro1E2, to incorporate five achiral dαAAs …
Ribosomal γ-Amino Acids
Suga Lab
Researchers in the Hiroaki Suga Group at the University of Tokyo hypothesize in the Journal of the American Chemical Society, that the conformational constraint …
Budding Immunity
Mayo Group
Immune cells naturally release extracellular vesicles studded with peptide-MHC complexes that can orchestrate immune responses, either directly stimulating T cells or transferring their cargo to …
Pyroglutamate Labeling
Ball Lab
Scientists in the laboratories of Professors Zachary Ball and Laura Segatori at Rice University have developed a photoredox catalysis method that enables site-selective modification of …
Mapping Membrane Activity
Hennig & Nau Labs
Cell-penetrating peptides and antimicrobial peptides both interact with lipid membranes, but with fundamentally different outcomes. Cell-penetrating peptides slip through membranes while leaving them largely intact, …
Dual Targeting Dendrimers
Alderete & Jiménez Labs
Tumor blood vessels differ from healthy vasculature in ways that drug developers can exploit. Endothelial cells lining tumor vessels overexpress E-selectin, a glycoprotein normally involved …
Fluorinated Viral Mimics
Matsuura Lab
Messenger RNA therapeutics have transformed medicine, from vaccines against infectious diseases to emerging applications in cancer immunotherapy and genome editing. Unlike DNA-based treatments that require …
Covalent Library Design
Derda Group
Researchers in the Derda Group at the University of Alberta, published in Biochemistry, have surveyed the emerging field of covalent genetically-encoded libraries for discovering …
Leader-Dependent Prenylation
Agarwal Lab
Lipidation of macrocyclic peptides represents a pharmaceutically important chemical transformation. Adding lipid groups to peptides can enhance antibiotic activity, alter membrane transport properties, and improve …
Tryptophan Transformation
Grob and Morandi Labs
A collaboration between the laboratories of Professor Bill Morandi in the Laboratorium für Organische Chemie and Dr. Nathalie Grob in the Institute of Pharmaceutical Sciences, …
Evolved Photo-Cross-Linkers
Yoo & Kim Labs
Antibody conjugates represent a cornerstone of modern therapeutics, diagnostics, and imaging. By attaching payloads such as cytotoxins, fluorophores, or radionuclides to immunoglobulins, researchers can harness …
Cyclic Cell Anchors
Yamada Group
Researchers in the Yamada Group at Tokyo University of Pharmacy and Life Sciences, published in Biochemistry, have systematically characterized LDV-derived peptides as cell-adhesive molecules …
Supra-Bivalent Inhibitors
Sengoku and Suga Labs
A collaboration between the laboratories of Professor Hiroaki Suga at the University of Tokyo and Professor Toru Sengoku at Yokohama City University has developed a …
Mirrored for Stability
Luo Lab
T-cell immunoglobulin and mucin domain 3, TIM-3, ranks among the most promising immune checkpoint targets in oncology. Expressed on exhausted T cells, natural killer cells, …
Cysteine Boronation
Bandyopadhyay Lab
Boronic acids have earned a versatile reputation in chemical biology and drug design. Their empty p orbital allows dynamic switching between sp2 and sp …
Tryptophan N-Sulfenylation
Yuan Lab
Peptides have become increasingly important as drug candidates and research tools due to their favorable safety profiles and ability to modulate protein-protein interactions. However, native …
Targeted Evolution
Jumi Shin Lab
Rational protein design can create remarkable molecules, but it explores only a sliver of sequence space. The Shin group at the University of Toronto has …
Cytosolic Delivery
Beck-Sickinger Lab
Therapeutic peptides offer a powerful strategy for disrupting intracellular protein-protein interactions that small molecules cannot effectively target. However, delivering peptides to the cytosol presents a …
Oxytocin Receptor Imaging
Wuest Lab
Breast cancer remains a leading cause of cancer-related death worldwide, with tumor heterogeneity and absent biomarkers limiting diagnostic and therapeutic options. While PET tracers targeting …
Programmable Peptide Coacervates
Tian Lab
Peptide-based coacervates have emerged as versatile platforms for drug delivery, tissue scaffolding, bioreactor systems, and cellular regulation due to their sequence programmability, dynamic self-assembly, and …
Conditional Miniprotein Activation
Oller-Salvia Lab
Protein therapeutics have transformed treatment of diseases from cancer to immune disorders, yet many targets appear not only at diseased sites but also in healthy …