Peptide Publications Archive
Grafted Coiled Coils
Andrew J. Lab
Protein–protein interactions, PPIs, are fundamental to cellular regulation, yet targeting them therapeutically remains challenging due to their extensive, shallow interfaces. Peptides offer an attractive solution, …
Efficient siRNA Delivery
Anders Lab
In this collaborative study, published in Bioconjugate Chemistry by researchers from the Dahlén group at Astra-Zeneca, Gothenburg, Sweden, and the Andaloussi team at the Karolinska …
Potent Antifungal Lipopeptide
Süssmuth Lab
In this study, researchers from the Süssmuth group at the Technische Universität Berlin, published in the Journal of the American Chemical Society, elucidated the …
Oxidative Peptide Coupling
Proulx Lab
This study demonstrates that a key determinant of this reactivity is the choice of solvent. By shifting from aqueous buffer to a mixed organic solvent …
Molecular Scaffolds
Craik Lab
This comprehensive review from the labs of David Craik and Lara Malins at Australian Research Council Centre of Excellence for Innovations in Peptide and Protein …
Quorum Sensing
Tal-Gan Lab
Streptococcus cristatus, a commensal member of the oral microbiota and recently reclassified from Streptococcus oligofermentans, has emerged as a promising candidate in the …
From Hydrogel to Crystal
Schneider Lab
Published in the Journal of the American Chemical Society, researchers in the lab of Dr. Joel P. Schneider at NIH, have unveiled a groundbreaking …
Sequence Architecture
Woolfson Lab
The Woolfson Lab continues to break new ground in de novo protein design with the successful creation of mixed-charge A3B3 heterohexameric α-helical …
Versatile Precursors
Mitchell Lab
Cyclopropane-containing amino acids, prized for their conformational rigidity and stability, are of increasing interest in therapeutic peptide development and antimicrobial drug discovery. A recent study …
Ubiquitin Azapeptide Esters
Liu Lab
Published as an ASAP article in the Journal of the American Chemical Society, researchers from the Wenshe Liu Lab at Texas A&M, currenly our …
Capturing the Uncatchable
Arora Lab
In a major step forward, researchers in the Arora Group at the New York University, have now developed a rationally designed proteomimetic receptor capable of …
Dynamic Ion Channels
Niitsu Lab
Membrane-spanning peptides that form ion-conductive channels remain a challenging frontier in de novo protein design. While strides have been made in creating water-soluble peptide assemblies, …
Antimicrobial Peptide
D'Amelio Lab
As antibiotic resistance surges worldwide, the search for effective new therapeutics has led scientists to a surprising source: the venom of Bungarus fasciatus, the …
Protein Design
Tezcan Lab
Isopeptide bonds, IPBs, — covalent linkages between the side chains of lysine and asparagine/glutamine or aspartate/glutamate — are remarkable for their chemical resilience and structural …
Enlicitide Decanoate
Thaisrivongs Lab
The total synthesis and process development of enlicitide decanoate, MK-0616, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9, PCSK9, represents a major breakthrough …
Arginine Carbonylation
Raj Lab
The selective incorporation of post-translational modifications, PTMs, into proteins remains a key challenge in chemical biology, particularly for modifications like arginine carbonylation, which plays a …
Vesicle Inversion
Deming Lab
Self-assembled polymeric vesicles that respond to biologically relevant stimuli have significant potential in drug delivery and synthetic biology. While many stimuli-responsive assemblies disassemble upon activation, …
Electrophilic Warheads
Research Lab
Understanding how proteins interact with biological metabolites is crucial for deciphering biological processes and advancing therapeutic strategies. This study focuses on a specific class of …
Selective Coupling
Suga Lab
α,β-Dehydroalanine, ΔAla, is a highly reactive nonproteinogenic amino acid that serves as a versatile handle for modifying peptides, natural products, NPs, and proteins. While many …
Vancomycin–Teixobactin
Nowick Lab
Vancomycin, a cornerstone antibiotic for Gram-positive infections, faces diminishing efficacy due to the emergence of vancomycin-resistant Enterococci, VRE, and vancomycin-resistant...
Synthesis Tag
Hartrampf Lab
Solid-phase peptide synthesis, SPPS, and native chemical ligation, NCL, are powerful methods for obtaining peptides and proteins that are otherwise inaccessible...
Peptide Modifications
Phan Lab
Ribosomally synthesized and post-translationally modified peptides, RiPPs, represent an expanding class of natural products distinguished by their extensive post-translational modifications. Among the enzymatic systems...
Genome Mining
Agarwal Lab
Brominated intermediates have long been favored in organic synthesis for their chemical versatility, particularly in transition-metal-assisted bond-forming reactions. The Agarwal and van der Donk study …
Backbone Editing
Schepartz Lab
The ability to precisely manipulate the peptide backbone remains one of the fundamental challenges in biomolecular engineering. While ribosomal translation and peptide synthesis methods allow …