Peptide Publications Archive
Guided Precision
Waser Lab
Cysteine residues attract chemical attention. Their nucleophilic thiol groups react readily with electrophiles, making them popular handles for attaching drugs, fluorophores, and other payloads to …
Crossing Cell Barriers
Meldal Lab
The cell membrane stands as biology's most formidable gatekeeper. Large molecules, from therapeutic proteins to diagnostic agents, cannot simply walk through. This barrier has frustrated …
Photoclick Bicycles
Lei Lab
Bicyclic peptides offer exceptional promise for targeting protein-protein interactions, combining the conformational rigidity needed for high-affinity binding with improved metabolic stability. Yet their construction remains …
Borrowed Machinery
Xu Lab
N-myristoylation is a common posttranslational modification in which the enzyme N-myristoyltransferase, NMT, attaches a 14-carbon fatty acid to an N-terminal glycine residue. This lipid anchor …
Modeling Selectivity
Miller Lab
Chiral sulfur compounds are gaining traction in drug discovery. Unlike their achiral counterparts, molecules with stereogenic sulfur centers often show improved potency and selectivity. IFM …
Masked Sugars
Dong Lab
Chemical synthesis provides atomic-level control over glycoprotein structure, yet hydrophobic sequences often aggregate before chemists can purify or ligate them. This problem may intensify for …
Helical Hijackers
Cai Lab
The Wnt/β-catenin signaling pathway governs embryonic development, stem cell maintenance, and tissue homeostasis. When aberrantly activated, it drives colorectal cancer and other malignancies. Inside the …
β-Hairpin Oligomers
Nowick Lab
Researchers in the Nowick Group at the University of California Irvine, reveal how a designed β-hairpin peptide derived from amyloid-β, Aβ, crosses the boundary from …
Gelatinase Targeting
Amitava Lab
Antibiotic resistance in Staphylococcus aureus thrives on biofilm fortifications and membrane resilience, which blunt broad-spectrum drugs and damage commensal flora. A modular short peptide, Py-FGGK, …
Optimizing Peptide Switches
Maly Lab
Chemically-controlled genetic tools allow researchers to switch cellular processes on or off with small molecules, offering precise temporal and dose-dependent control. While chemically-inducible dimerization systems …
Taming Arginine
Raj Lab
Selective modification of amino acid side chains has become a central strategy for expanding peptide function beyond the limits of ribosomal chemistry. Yet one residue …
TCR Peptide Design
Nourmohammad Lab
In work published in PNAS, Visani and colleagues from the University of Washington, introduce a structure-aware machine learning approach that forecasts TCR–peptide–MHC interactions and …
Iodo Quantification
Lilienkampf Lab
In work published in ACS Chemical Biology, David J. Clarke, Annamaria Lilienkampf, and collaborators from the University of Edinburgh, introduce an iodo based labeling strategy …
Docking Bias
Keating Lab
Deep-learning structure predictors now place many peptides correctly onto their protein partners, and this recent work from Lindsey Guan and Amy Keating at the Massachusetts …
Dilp Divergence
Bland Lab
Insulin-like peptides orchestrate how animals apportion nutrients between storage and growth, yet distinct ligands may encode different cues even when signaling through a single receptor. …
Sequence Hydrophobicity
Perry Lab
In this study, published in Biomacromolecules, researchers in Sarah Perry's group at the University of Massachusetts - Amherst, employ sequence-defined polypeptides as minimal models …
Affinity Landscapes
Bussemaker Lab
A collaborative study from the Bussemaker and Shah Groups at Columbia University, published in Protein Science, establishes an integrated experimental–computational framework, built on massively …
Alkyne Grasp
Fujishiro Lab
ATP-grasp ligases offer a powerful route to diversify peptide structures, and BesA stands out for its ability to incorporate terminal alkyne groups into dipeptides with …
Aquaporin Bridge
Wang Lab
Researchers from the Wang Group at the School of Life Sciences, Shandong University, China, report in PNAS a mechanistic bridge between two pillars of arthropod …
Peptide Portals
Otto Lab
For decades, antimicrobial peptides, AMPs, have stood at the crossroads between innate immunity and drug discovery, yet their molecular diversity remains incompletely explored. Dickey, Otto, …
Glycan–Metal Synergy
Koksch Lab
Hydrogels, highly hydrated polymer networks, underpin both natural barriers such as mucus and numerous biomedical applications. Mucins, the glycoprotein constituents of mucus, achieve their viscoelasticity …
Phosphine Rebridging
Hackenberger Lab
Published in Angewandte Chemie International Editition, researchers from the Hackenberger Lab at the Humboldt-Universität in Berlin, present a powerful new class of phosphine oxide–based …
Helical Hydrazides
Gellman Lab
Seeking to understand the relative kinetic benefits of reactive unit connection and preorganization, researchers from the Gellman Lab at the University of Wisconsin–Madison investigated α/β-peptide …
Serine Switch
Diao Lab
Published in the Journal of the American Chemical Society, work by first author Zhenyan Guo in the Diao Lab at the New York University, …