Peptide Publications Archive
Proline Scanning
Wu Lab
Disulfide-rich peptides, DRPs, are renowned for their stability and therapeutic promise, yet their natural structures offer limited flexibility for evolution or functional adaptation. In an …
Shaping Peptide Assemblies
Jiang Lab
Peptides capable of folding into defined secondary structures serve as promising modular building blocks for supramolecular materials. However, conventional approaches to peptide-based self-assembly are often …
Delivery of Peptide-LYTAC
Luan Lab
While immune checkpoint blockade, ICB, therapies have transformed cancer immunotherapy, tumors such as melanoma frequently exploit the CD47-SIRPα axis to evade macrophage-mediated clearance. Antibody-based CD47 …
Peptide Anti Obesity 2.0
David Lab
Obesity is a leading contributor to global disease burden and a primary risk factor for type 2 diabetes, yet current treatments often lack specificity and …
Intracellular Targeting
Futaki Lab
The delivery of biomacromolecules directly into the cytosol remains a central challenge in therapeutic peptide science. Coacervate-based systems offer a promising platform, yet many are …
Rational Design
Gellman Lab
The rational construction of stable hetero-oligomeric protein complexes with defined subunit composition is a central challenge in molecular design. In this study, published in the …
Quorum Sensing Redux
Tal-Gan Lab
Streptococcus constellatus, a member of the Streptococcus anginosus group, SAG, is an opportunistic pathogen commonly found in the human oral and gastrointestinal microbiota. While …
Macrocyclic Peptide Antibiotics
van der Donk Lab
Ribosomally synthesized and posttranslationally modified peptides, RiPPs, represent one of the most structurally diverse classes of natural products, yet many RiPP families remain biosynthetically uncharacterized...
Conjugation Chemistry
Kwon Lab
Traumatic brain injury, TBI, remains a profound and unresolved clinical challenge, responsible for long-term disability in both civilian and military populations. The lack of effective …
Grafted Coiled Coils
Andrew J. Lab
Protein–protein interactions, PPIs, are fundamental to cellular regulation, yet targeting them therapeutically remains challenging due to their extensive, shallow interfaces. Peptides offer an attractive solution, …
Efficient siRNA Delivery
Anders Lab
In this collaborative study, published in Bioconjugate Chemistry by researchers from the Dahlén group at Astra-Zeneca, Gothenburg, Sweden, and the Andaloussi team at the Karolinska …
Potent Antifungal Lipopeptide
Süssmuth Lab
In this study, researchers from the Süssmuth group at the Technische Universität Berlin, published in the Journal of the American Chemical Society, elucidated the …
Oxidative Peptide Coupling
Proulx Lab
This study demonstrates that a key determinant of this reactivity is the choice of solvent. By shifting from aqueous buffer to a mixed organic solvent …
Molecular Scaffolds
Craik Lab
This comprehensive review from the labs of David Craik and Lara Malins at Australian Research Council Centre of Excellence for Innovations in Peptide and Protein …
Quorum Sensing
Tal-Gan Lab
Streptococcus cristatus, a commensal member of the oral microbiota and recently reclassified from Streptococcus oligofermentans, has emerged as a promising candidate in the …
From Hydrogel to Crystal
Schneider Lab
Published in the Journal of the American Chemical Society, researchers in the lab of Dr. Joel P. Schneider at NIH, have unveiled a groundbreaking …
Sequence Architecture
Woolfson Lab
The Woolfson Lab continues to break new ground in de novo protein design with the successful creation of mixed-charge A3B3 heterohexameric α-helical …
Versatile Precursors
Mitchell Lab
Cyclopropane-containing amino acids, prized for their conformational rigidity and stability, are of increasing interest in therapeutic peptide development and antimicrobial drug discovery. A recent study …
Ubiquitin Azapeptide Esters
Liu Lab
Published as an ASAP article in the Journal of the American Chemical Society, researchers from the Wenshe Liu Lab at Texas A&M, currenly our …
Capturing the Uncatchable
Arora Lab
In a major step forward, researchers in the Arora Group at the New York University, have now developed a rationally designed proteomimetic receptor capable of …
Dynamic Ion Channels
Niitsu Lab
Membrane-spanning peptides that form ion-conductive channels remain a challenging frontier in de novo protein design. While strides have been made in creating water-soluble peptide assemblies, …
Antimicrobial Peptide
D'Amelio Lab
As antibiotic resistance surges worldwide, the search for effective new therapeutics has led scientists to a surprising source: the venom of Bungarus fasciatus, the …
Protein Design
Tezcan Lab
Isopeptide bonds, IPBs, — covalent linkages between the side chains of lysine and asparagine/glutamine or aspartate/glutamate — are remarkable for their chemical resilience and structural …
Enlicitide Decanoate
Thaisrivongs Lab
The total synthesis and process development of enlicitide decanoate, MK-0616, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9, PCSK9, represents a major breakthrough …