Peptide Publications Archive
Optimizing Peptide Switches
Maly Lab
Chemically-controlled genetic tools allow researchers to switch cellular processes on or off with small molecules, offering precise temporal and dose-dependent control. While chemically-inducible dimerization systems …
Taming Arginine
Raj Lab
Selective modification of amino acid side chains has become a central strategy for expanding peptide function beyond the limits of ribosomal chemistry. Yet one residue …
TCR Peptide Design
Nourmohammad Lab
In work published in PNAS, Visani and colleagues from the University of Washington, introduce a structure-aware machine learning approach that forecasts TCR–peptide–MHC interactions and …
Iodo Quantification
Lilienkampf Lab
In work published in ACS Chemical Biology, David J. Clarke, Annamaria Lilienkampf, and collaborators from the University of Edinburgh, introduce an iodo based labeling strategy …
Docking Bias
Keating Lab
Deep-learning structure predictors now place many peptides correctly onto their protein partners, and this recent work from Lindsey Guan and Amy Keating at the Massachusetts …
Dilp Divergence
Bland Lab
Insulin-like peptides orchestrate how animals apportion nutrients between storage and growth, yet distinct ligands may encode different cues even when signaling through a single receptor. …
Sequence Hydrophobicity
Perry Lab
In this study, published in Biomacromolecules, researchers in Sarah Perry's group at the University of Massachusetts - Amherst, employ sequence-defined polypeptides as minimal models …
Affinity Landscapes
Bussemaker Lab
A collaborative study from the Bussemaker and Shah Groups at Columbia University, published in Protein Science, establishes an integrated experimental–computational framework, built on massively …
Alkyne Grasp
Fujishiro Lab
ATP-grasp ligases offer a powerful route to diversify peptide structures, and BesA stands out for its ability to incorporate terminal alkyne groups into dipeptides with …
Aquaporin Bridge
Wang Lab
Researchers from the Wang Group at the School of Life Sciences, Shandong University, China, report in PNAS a mechanistic bridge between two pillars of arthropod …
Peptide Portals
Otto Lab
For decades, antimicrobial peptides, AMPs, have stood at the crossroads between innate immunity and drug discovery, yet their molecular diversity remains incompletely explored. Dickey, Otto, …
Glycan–Metal Synergy
Koksch Lab
Hydrogels, highly hydrated polymer networks, underpin both natural barriers such as mucus and numerous biomedical applications. Mucins, the glycoprotein constituents of mucus, achieve their viscoelasticity …
Phosphine Rebridging
Hackenberger Lab
Published in Angewandte Chemie International Editition, researchers from the Hackenberger Lab at the Humboldt-Universität in Berlin, present a powerful new class of phosphine oxide–based …
Helical Hydrazides
Gellman Lab
Seeking to understand the relative kinetic benefits of reactive unit connection and preorganization, researchers from the Gellman Lab at the University of Wisconsin–Madison investigated α/β-peptide …
Serine Switch
Diao Lab
Published in the Journal of the American Chemical Society, work by first author Zhenyan Guo in the Diao Lab at the New York University, …
Ephemeral Pores
Pastor Lab
In a PNAS study, researchers from the Pastor group at the National Institutes of Health, NIH, and the Cotten group at Oregon State University present …
Copper Clicks
Metanis Lab
In a collaborative work between the Metanis and Shimon labs at the Hebrew University of Jerusalem, and the Wang group at the Xiamen University in …
Mitochondrial Click
Wennemers Lab
In work published in ACS Chemical Biology, Adeline Schmitt, under the guidance of Helma Wennemers at ETH Zürich, investigated rigid polyproline II, PPII, helical …
Covalent Peptide Libraries
Bode Lab
Covalent inhibitors provide potent and durable target engagement, with approved drugs such as ibrutinib and osimertinib validating the approach. These compounds exploit electrophilic warheads to …
Lanthipeptide Modeling
Walker Lab
Lanthipeptides, the thioether-crosslinked members of the RiPP family, are compelling antibiotic scaffolds. Yet, they have remained largely outside the reach of structure-based design. Standard modeling …
Photoregulated Catalysis
Bandyopadhyay Lab
Precise external regulation of enzymatic activity remains a central goal in chemical biology, with wide-ranging implications for biotechnology, diagnostics, and medicine. Natural proteases govern countless …
Peptide Aggregation Blockers
Wright Lab
The misfolding and aggregation of transthyretin, TTR, a serum protein responsible for transporting thyroxine and retinol binding protein, underlies a class of amyloid diseases that …
Engineered Lasso Peptides
Burk Lab
A major barrier to durable responses with PD-1/PD-L1 checkpoint inhibitors is the activation of immunosuppressive TGF-β within the tumor microenvironment. This immunosuppression is driven in …
Spike Peptide Amyloids
Legleiter Lab
SARS-CoV-2 spike protein fragments are known to form amyloid fibrils, but far less is understood about the prefibrillar states that emerge along the way, or …