Peptide Publications Archive
Bifunctional Peptide Oxidation
Miller Lab
Axially chiral biaryl aldehydes are prized scaffolds in medicinal chemistry and asymmetric catalysis, yet enantioselective aerobic oxidations to access them have remained elusive. A new …
Wnt5a Competitor
Suga Lab
Diffuse intrinsic pontine glioma, DIPG, kills most children within two years of diagnosis and resists virtually every treatment tried so far. Now, a macrocyclic peptide …
Integrity Shapes Selection
Hampton and Liu labs
When a protein target is tethered to a solid support for phage display, does the immobilization chemistry matter? Researchers at Texas A&M engineered three structurally …
Ribosome Peptide Mining
Kurkcuoglu Lab
The bacterial ribosome is a proven antibiotic target, yet peptide-based modulation of its allosteric machinery remains largely uncharted. A new multiscale computational pipeline screens thousands …
Peptide Reveals Oligomers
Gandy, Arancio, Ehrlich, Guérin, Lubell, and Rahimipour Labs
A multi-institutional team supervised jointly by Sam Gandy, Ottavio Arancio, and Michelle Ehrlich, published in Alzheimer's Dement., turned a designed cyclic D,L-α-peptide into a …
Locking Out RAS
Therrien Lab
Resistance to approved RAS inhibitors emerges rapidly in patients, driven by secondary mutations at the Switch-II and cyclophilin-A binding pockets. A team at Université de …
GLP-1s Block Amyloid
Limbocker Lab
Millions of people already take GLP-1 receptor agonists for diabetes and weight loss, but whether these drugs directly interfere with the molecular machinery of Alzheimer's …
Profiling Transpeptidase Targets
Pires Lab
Tuberculosis kills more than a million people each year, yet the enzymes that stitch together its cell wall remain poorly understood and difficult to target. …
Steering Cysteine Chemistry
Tsai Lab
Most reagents that target N-terminal cysteine consume both the amine and thiol, locking the ligation site into an inert heterocycle. A new steric-control strategy forces …
Paired Library Pursuit
Suga Lab
Most peptide discovery platforms find one binder at a time. A new library-vs-library extension of the RaPID system pairs two 10¹²-member macrocyclic peptide libraries and …
Hydrazino Turn Hunters
Suga Lab
α-Hydrazino acids have long tantalized peptide chemists with their turn-inducing and protease-resisting properties, yet no one had managed to screen them de novo against protein …
Backbone Heteroatom Shield
Del Valle Lab
Replacing backbone amide nitrogens with nitrogen or oxygen heteroatoms can slow protease degradation without sacrificing the folded structures peptides need to work. A tetra-N-aminated antimicrobial …
Breaching Candida
van der Donk Lab
A class II lanthipeptide from the cyanobacterium Nostoc punctiforme kills Candida species by disrupting cell membranes, marking the first antifungal activity reported for this lanthipeptide …
Tuning Incretin Balance
Kumar Lab
A single chemical edit at the N-terminus of a GLP-1/GIP/glucagon multiagonist can shift receptor potency balance by orders of magnitude, selectively suppress β-arrestin recruitment, or …
Stapling LRRK2
Kennedy Lab
Hydrocarbon-stapled peptides that mimic the C-terminal helix of LRRK2 can penetrate cells, bind the kinase directly, and suppress its hyperactivation without triggering the mislocalization side …
Yeast Finds Inhibitors
Angelini Lab
Yeast display technology, long used to evolve antibodies, can now rapidly surface macrocyclic peptide inhibitors of human angiotensin-converting enzyme 2 with potencies in the low-nanomolar …
Chameleonic Proline Rings
Palma Lab
A new family of all-peptide macrocycles built from alternating L- and D-proline tetramers flips between two distinct conformations depending on solvent, solves long-standing functionalization challenges …
Ansamers Target Integrins
Yao Lab
Bicyclic peptides derived from the amanitin scaffold can exist as non-interconvertible conformational isomers called ansamers, and the two mirror-like forms can differ by orders of …
Lipid-Hijacking RiPPs
van der Donk Lab
Bacteria already possess a well-oiled machinery for anchoring lipoproteins to their membranes. A new study reveals that a family of ribosomally synthesized peptides has co-opted …
DarF Decoded
Phan Lab
An enzyme in the darobactin biosynthetic pathway had been classified as a protease for years. New biochemical evidence shows it is actually an α-ketoglutarate-dependent oxidase …
Porous Collagen Crystals
Merg Lab
Collagen-mimetic peptides are renowned for triple-helix rigidity, but no one had channeled that rigidity into a porous crystalline framework. Now, by appending a single alkyl …
Scalable Azapeptide Macrocycles
Lubell Lab
A convergent solution-phase strategy for a potent macrocyclic azapeptide CD36 modulator sidesteps preparative chromatography entirely, delivering 100 mg of >99%-pure material by swapping an oligomer-prone …
Hairpins Hold the Key
Hall, Radford, and Brockwell Labs
A single methionine swap in α-synuclein's N-terminal P1 motif dismantles the β-hairpin architecture that normally launches amyloid fibril formation
Activating Native Termini
Raj Lab
Thiazoline and thiazole macrocycles embedded in bioactive marine peptides have long required pre-built specialty building blocks that slow synthesis and risk epimerization. A new palladium-mediated …